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rs3755351

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) >1.3x risk for hypertension
(A;C) 1.3x risk for hypertension
(C;C) normal
ReferenceGRCh38 38.1/141
Chromosome2
Position70747758
GeneADD2
is asnp
is mentioned by
dbSNPrs3755351
ebirs3755351
HLIrs3755351
Exacrs3755351
Varsomers3755351
Maprs3755351
PheGenIrs3755351
hapmaprs3755351
1000 genomesrs3755351
hgdprs3755351
ensemblrs3755351
gopubmedrs3755351
geneviewrs3755351
scholarrs3755351
googlers3755351
pharmgkbrs3755351
gwascentralrs3755351
openSNPrs3755351
23andMers3755351
23andMe allrs3755351
SNP Nexus

SNPshotrs3755351
SNPdbers3755351
MSV3drs3755351
GWAS Ctlgrs3755351
GMAF0.3448
Max Magnitude
? (A;A) (A;C) (C;C) 28
rs3755351, a SNP in the ADD2 gene, was associated with risk for hypertension in a study involving 1,500+ Japanese patients. The odds ratio associated with the risk allele, rs3755351(C), which is also the most common allele, is 1.30 (CI: 1.15 - 1.46, p = 0.00002). [PMID 18003638]

Note that a neighboring ADD2 SNP in close (r2 of 0.806) proximity, rs17006246, was associated with hypertension in a diabetes study [PMID 17463246]; however, in this case, it was in "the opposite direction of effect". This discrepancy has not been resolved. [PMID 18003638]