|(C;C)||1.1||increased risk of parkinson's disease|
|(C;T)||0||normal risk of parkinson's disease|
|(T;T)||0||normal risk of parkinson's disease|
[PMID 17905480] We provide evidence for a novel, strong and reproducible association of the PITX3 promoter SNP rs3758549 : C>T (p=0.004) with PD. The C-allele appears to be a recessive risk allele with an estimated population frequency of 83%.
[PMID 19345444] Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease.
[PMID 21138504] The transcription factor Pitx3 is a risk modifier for Parkinson's disease in a Chinese Han population
[PMID 21524731] PITX3 gene polymorphism is associated with Parkinson's disease in Chinese population
[PMID 21565251] Genetic variants of the PITX3 gene are not associated with late-onset sporadic Parkinson's disease in a Chinese population
[PMID 22411443] A novel synonymous SNP in PITX3 is associated with Parkinson's disease in Chinese population
[PMID 18420308] PITX3 polymorphism is associated with early onset Parkinson's disease.
[PMID 19754401] The role of transcription factor Pitx3 in dopamine neuron development and Parkinson's disease.
[PMID 22037506] PITX3 polymorphism is not associated with Parkinson's disease in a Chinese population.
[PMID 24394914] Association between PITX3 promoter polymorphism and risk of Parkinson's disease: The impact of ethnicity and onset age
[PMID 24525476] PITX3 and Risk for Parkinson's Disease: A Systematic Review and Meta-Analysis