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rs3761847(G;G)

From SNPedia

>1.32 x risk of rheumatoid arthritis
Is agenotype
ofrs3761847
GeneTRAF1
Chromosome9
Position120,927,961
mentionedby
Magnitude2.2
ReputeBad
Geno Mag Summary
(A;A) 0 normal
(A;G) 2.1 1.32 x risk of rheumatoid arthritis.
(G;G) 2.2 >1.32 x risk of rheumatoid arthritis

A common genetic variant at the TRAF1-C5 locus on chromosome 9 is associated with an increased risk of anti-CCP-positive rheumatoid arthritis. rs3761847, a SNP located between two genes associated with chronic inflammation (TRAF1 and C5), is associated with increased risk of anti CCP-positive rheumatoid arthritis. The risk allele is (G); the odds ratio reported is 1.32 (95% confidence interval, 1.23 to 1.42; P=4x10-14) [PMID 17804836].