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rs3764147

From SNPedia

Orientationplus
Stabilizedplus
Make rs3764147(A;A)
Make rs3764147(A;G)
Make rs3764147(G;G)
ReferenceGRCh38 38.1/141
Chromosome13
Position43883789
GeneLACC1
is asnp
is mentioned by
dbSNPrs3764147
ebirs3764147
HLIrs3764147
Exacrs3764147
Varsomers3764147
Maprs3764147
PheGenIrs3764147
hapmaprs3764147
1000 genomesrs3764147
hgdprs3764147
ensemblrs3764147
gopubmedrs3764147
geneviewrs3764147
scholarrs3764147
googlers3764147
pharmgkbrs3764147
gwascentralrs3764147
openSNPrs3764147
23andMers3764147
23andMe allrs3764147
SNP Nexus

SNPshotrs3764147
SNPdbers3764147
MSV3drs3764147
GWAS Ctlgrs3764147
GMAF0.3026
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS
SNP rs3764147
PubMedID [PMID 18587394OA-icon.png]
Condition Crohn's disease
Gene Unknown
Risk Allele G
pValue 2.00E-013
OR 1.25
95% CI



Variant in the C13orf31 region associated with increased susceptibility to leprosy, according to the 23andMe blog 23andMe blog. The risk allele is G, and the odds ratio is 1.68.

Other genes associated with both Crohn's disease and leprosy include NOD2 and TNFSF15, according to 23andMe's blog.

GWAS snp
PMID [PMID 20018961]
Trait Leprosy
Title Genomewide Association Study of Leprosy
Risk Allele G
P-val 4E-54
Odds Ratio 1.68 [1.57-1.80]
OMIM613407
Desc
Variant
Relatedalso


[PMID 25642632] Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.

[PMID 21304977OA-icon.png] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

[PMID 19068216OA-icon.png] Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.


GET Evidence
C13ORF31-I254V
aa_change Ile254Val
aa_change_short I254V
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.253858
summary



Leprosy Susceptibility

GWAS snp
PMID [PMID 23128233OA-icon.png]
Trait Crohn's disease
Title Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Risk Allele G
P-val 2E-21
Odds Ratio 1.16 [1.112-1.199]
GWAS snp
PMID [PMID 21102463OA-icon.png]
Trait Crohn's disease
Title Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Risk Allele G
P-val 1E-10
Odds Ratio 1.17 [1.12-1.23]


[PMID 23974994] Replication Study of Ulcerative Colitis Risk Loci in a Lithuanian-Latvian Case-Control Sample