Have questions? Visit https://www.reddit.com/r/SNPedia

rs3764650

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 Late onset?
(G;T) 0 Late onset?
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome19
Position1046521
GeneABCA7
is asnp
is mentioned by
dbSNPrs3764650
ebirs3764650
HLIrs3764650
Exacrs3764650
Varsomers3764650
Maprs3764650
PheGenIrs3764650
hapmaprs3764650
1000 genomesrs3764650
hgdprs3764650
ensemblrs3764650
gopubmedrs3764650
geneviewrs3764650
scholarrs3764650
googlers3764650
pharmgkbrs3764650
gwascentralrs3764650
openSNPrs3764650
23andMers3764650
23andMe allrs3764650
SNP Nexus

SNPshotrs3764650
SNPdbers3764650
MSV3drs3764650
GWAS Ctlgrs3764650
GMAF0.1997
Max Magnitude0
? (G;G) (G;T) (T;T) 28
Alzheimer's disease associated, based on large 2011 study 10.1038/ng.803

"The minor allele of Rs3764650 in ABCA7 was associated with a later age at onset and shorter disease course" according to http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511432/

GWAS snp
PMID [PMID 21460840OA-icon.png]
Trait
Title Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
Risk Allele
P-val 5E-17
Odds Ratio 1.2300 [1.18-1.30]


[PMID 23419238OA-icon.png] Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms


[PMID 23226438OA-icon.png] Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains


[PMID 23836404OA-icon.png] Genetic Susceptibility for Alzheimer Disease Neuritic Plaque Pathology


[PMID 24141082OA-icon.png] ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status


[PMID 23180304] Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease.


[PMID 23669301OA-icon.png] Interaction between two cholesterol metabolism genes influences memory: findings from the Wisconsin Registry for Alzheimer's Prevention.


[PMID 25189118] Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease


[PMID 26141617] Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study


[PMID 27103528] Association of genetic risk factors with cognitive decline: the PATH through life project.