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rs3784709

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1 Normal risk of developing restless legs syndrome
(C;T) 1.5 0.71x risk of developing restless legs syndrome
(T;T) 1.8 >0.71x risk of developing restless legs syndrome
ReferenceGRCh38 38.1/141
Chromosome15
Position67779937
GeneMAP2K5
is asnp
is mentioned by
dbSNPrs3784709
ebirs3784709
HLIrs3784709
Exacrs3784709
Varsomers3784709
Maprs3784709
PheGenIrs3784709
hapmaprs3784709
1000 genomesrs3784709
hgdprs3784709
ensemblrs3784709
gopubmedrs3784709
geneviewrs3784709
scholarrs3784709
googlers3784709
pharmgkbrs3784709
gwascentralrs3784709
openSNPrs3784709
23andMers3784709
23andMe allrs3784709
SNP Nexus

SNPshotrs3784709
SNPdbers3784709
MSV3drs3784709
GWAS Ctlgrs3784709
GMAF0.4711
Max Magnitude1.8
? (C;C) (C;T) (T;T) 28
rs3784709, a SNP located in a region of chromosome 15q, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.71 (CI: 0.60-0.83) for the (T) minor allele. [PMID 17637780]
Neighborrs4489954
Distance200
[PMID 19279021OA-icon.png] Replication of restless legs syndrome loci in three European populations.


GET Evidence
rs3784709
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.4375
summary