Have questions? Visit https://www.reddit.com/r/SNPedia

rs3792876

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0
Make rs3792876(C;T)
Make rs3792876(T;T)
ReferenceGRCh38 38.1/141
Chromosome5
Position132301616
GeneSLC22A4
is asnp
is mentioned by
dbSNPrs3792876
ebirs3792876
HLIrs3792876
Exacrs3792876
Varsomers3792876
Maprs3792876
PheGenIrs3792876
hapmaprs3792876
1000 genomesrs3792876
hgdprs3792876
ensemblrs3792876
gopubmedrs3792876
geneviewrs3792876
scholarrs3792876
googlers3792876
pharmgkbrs3792876
gwascentralrs3792876
openSNPrs3792876
23andMers3792876
23andMe allrs3792876
SNP Nexus

SNPshotrs3792876
SNPdbers3792876
MSV3drs3792876
GWAS Ctlgrs3792876
GMAF0.1304
Max Magnitude0
? (C;C) (C;T) (T;T) 28
NOTE: information for rs1050152 was accidentally entered for this SNP, rs3792876. Although the SNPs are in the same gene, the original reference does not specifically refer to rs3792876 and the degree of linkage has not been confirmed.

rs1051052, a SNP in the SLC22A4 gene known as L503F, has been associated with an autoimmune disease, in this case, Crohn's disease, odds ratio = 2.1 (CI = 1.31–3.39, p = 0.002), based on a study of 203 cases and 200 controls. The risk allele is rs1050152(T).[PMID 15107849]

A nearby SNP in the promoter region of the SLC22A5 gene defines a haplotype along with rs3792876, with odds ratio reported as similar for either SNP or the haplotype.[PMID 15107849]

[PMID 18709696] rs2073838 and rs3792876 replicated for rheumatoid arthritis in Japanese, but not Caucasian populations.

[PMID 18087673] rs3792876 failed to showed a statistically significant association with rheumatoid arthritis



[PMID 15751072] Investigation of the SLC22A4 gene (associated with rheumatoid arthritis in a Japanese population) in a United Kingdom population of rheumatoid arthritis patients.


[PMID 16519819OA-icon.png] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.


[PMID 16796743OA-icon.png] Evidence for the association of the SLC22A4 and SLC22A5 genes with type 1 diabetes: a case control study.


[PMID 17476680] Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease.


[PMID 19840389OA-icon.png] Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria.


[PMID 19956108OA-icon.png] Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.


[PMID 20444268OA-icon.png] Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.


GET Evidence
rs3792876
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0859375
summary May be associated with Crohn disease.



[PMID 25707686] Association of joint erosion with SLC22A4 gene polymorphisms inconsistently associated with rheumatoid arthritis susceptibility