|| Among asthmatics, 1.5x more likely to show less response to inhaled glucocorticoids
|| Among asthmatics, 2.3x more likely to show less response to inhaled glucocorticoids
is a SNP in the promoter region of the glucocorticoid induced transcript 1 GLCCI1
gene on chromosome 7.
Based on 4 populations totaling 900+ asthma patients, the rs37973(G) allele was associated (p = 0.0007, pooled data) with lower amounts of improvement of lung function in response to inhaled glucocorticoids such as budesonide. The mean (±SE) increase in forced expiratory volume in 1 second (FEV1) in treated rs37973(G;G) patients was about one third of that seen in rs37973(A;A) patients (3.2±1.6% vs. 9.4±1.1%). Based on dividing the response into highest vs lowest quartiles of response, the allelic odds ratio of falling into the lowest responding quartile based on an additive genetic model was calculated to be 1.52 (CI: 1.13 - 2.03). Genotype accounted for about 7% of overall inhaled glucocorticoid response variability.10.1056/NEJMoa0911353
|?|| (A;A) (A;G) (G;G) ||28|
] Predicting inhaled corticosteroid response in asthma with two associated SNPs.
[PMID 25091946] Admixture of beneficial and unfavourable variants of GLCCI1 and FCER2 in Roma samples can implicate different clinical response to corticosteroids
[PMID 25134782] Rs37972 and rs37973 single-nucleotide polymorphisms in the Glucocorticoid-inducible 1 gene are not associated with asthma risk in a Saudi Arabian population