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rs37973

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;G) 1.8 Among asthmatics, 1.5x more likely to show less response to inhaled glucocorticoids
(G;G) 2.3 Among asthmatics, 2.3x more likely to show less response to inhaled glucocorticoids
ReferenceGRCh38 38.1/141
Chromosome7
Position7968245
GeneAC009473.1, GLCCI1
is asnp
is mentioned by
dbSNPrs37973
ebirs37973
HLIrs37973
Exacrs37973
Varsomers37973
Maprs37973
PheGenIrs37973
hapmaprs37973
1000 genomesrs37973
hgdprs37973
ensemblrs37973
gopubmedrs37973
geneviewrs37973
scholarrs37973
googlers37973
pharmgkbrs37973
gwascentralrs37973
openSNPrs37973
23andMers37973
23andMe allrs37973
SNP Nexus

SNPshotrs37973
SNPdbers37973
MSV3drs37973
GWAS Ctlgrs37973
GMAF0.3921
Max Magnitude2.3
rs37973 is a SNP in the promoter region of the glucocorticoid induced transcript 1 GLCCI1 gene on chromosome 7.

Based on 4 populations totaling 900+ asthma patients, the rs37973(G) allele was associated (p = 0.0007, pooled data) with lower amounts of improvement of lung function in response to inhaled glucocorticoids such as budesonide. The mean (±SE) increase in forced expiratory volume in 1 second (FEV1) in treated rs37973(G;G) patients was about one third of that seen in rs37973(A;A) patients (3.2±1.6% vs. 9.4±1.1%). Based on dividing the response into highest vs lowest quartiles of response, the allelic odds ratio of falling into the lowest responding quartile based on an additive genetic model was calculated to be 1.52 (CI: 1.13 - 2.03). Genotype accounted for about 7% of overall inhaled glucocorticoid response variability.10.1056/NEJMoa0911353

? (A;A) (A;G) (G;G) 28
[PMID 22641026OA-icon.png] Predicting inhaled corticosteroid response in asthma with two associated SNPs.


[PMID 25091946] Admixture of beneficial and unfavourable variants of GLCCI1 and FCER2 in Roma samples can implicate different clinical response to corticosteroids


[PMID 25134782] Rs37972 and rs37973 single-nucleotide polymorphisms in the Glucocorticoid-inducible 1 gene are not associated with asthma risk in a Saudi Arabian population


ClinVar
Risk rs37973(A;A)
Alt rs37973(A;A)
Reference rs37973(G;G)
Significance Drug-response
Disease Glucocorticoid therapy
Variation info
Gene GLCCI1 LOC100505921
CLNDBN Glucocorticoid therapy, response to
Reversed 0
HGVS NC_000007.13:g.8007876G\x3d
CLNSRC OMIM Allelic Variant
CLNACC RCV000024148.1,