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rs3800779

From SNPedia

Orientationminus
Stabilizedplus
Make rs3800779(G;G)
Make rs3800779(G;T)
Make rs3800779(T;T)
ReferenceGRCh38 38.1/142
Chromosome7
Position150974126
GeneKCNH2
is asnp
is mentioned by
dbSNPrs3800779
ebirs3800779
HLIrs3800779
Exacrs3800779
Varsomers3800779
Maprs3800779
PheGenIrs3800779
hapmaprs3800779
1000 genomesrs3800779
hgdprs3800779
ensemblrs3800779
gopubmedrs3800779
geneviewrs3800779
scholarrs3800779
googlers3800779
pharmgkbrs3800779
gwascentralrs3800779
openSNPrs3800779
23andMers3800779
23andMe allrs3800779
SNP Nexus

SNPshotrs3800779
SNPdbers3800779
MSV3drs3800779
GWAS Ctlgrs3800779
GMAF0.2204
Max Magnitude
g2b2mh rs3800779 rs748693 and rs1036145 are associated with a variety of brain parameters such as hippocampal volume, hippocampal activity (declarative memory task) and activity in the dorsolateral prefrontal cortex (DLPFC). The main suggestion of how these variants in KCNH2 might lead to these brain changes and risk for schizophrenia comes from previous findings that mutations in this gene screw up the efflux of K+ ions during the repolarization phase of an action potential.

[PMID 20507645OA-icon.png] Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study