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rs3802177

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 1.16x increased risk for type-2 diabetes
(C;T) 1.16x increased risk for type-2 diabetes
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome8
Position117172786
GeneSLC30A8
is asnp
is mentioned by
dbSNPrs3802177
ebirs3802177
HLIrs3802177
Exacrs3802177
Varsomers3802177
Maprs3802177
PheGenIrs3802177
hapmaprs3802177
1000 genomesrs3802177
hgdprs3802177
ensemblrs3802177
gopubmedrs3802177
geneviewrs3802177
scholarrs3802177
googlers3802177
pharmgkbrs3802177
gwascentralrs3802177
openSNPrs3802177
23andMers3802177
23andMe allrs3802177
SNP Nexus

SNPshotrs3802177
SNPdbers3802177
MSV3drs3802177
GWAS Ctlgrs3802177
GMAF0.2833
Max Magnitude0
? (C;C) (C;T) (T;T) 28

[PMID 18477659] rs3802177 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.16 (CI: 1.05-1.27, p = 4.5 x 10e-3)

Note: this SNP is fairly tightly linked (r2 = 0.83) to another SNP in the SLC30A8 gene also linked to type-2 diabetes, rs13266634

Neighborrs13266634
Distance242
GWAS snp
PMID [PMID 20581827OA-icon.png]
Trait Type 2 diabetes
Title Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Risk Allele G
P-val 1E-8
Odds Ratio 1.15 [1.10-1.21]


[PMID 18469204OA-icon.png] Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.


[PMID 20550665OA-icon.png] Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.


[PMID 20554072] Gestational diabetes mellitus screening based on the gene chip technique.

GWAS snp
PMID [PMID 22693455OA-icon.png]
Trait
Title Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
Risk Allele G
P-val 4E-8
Odds Ratio 1.2300 None
GWAS snp
PMID [PMID 24509480OA-icon.png]
Trait Type 2 diabetes
Title Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Risk Allele G
P-val 2E-18
Odds Ratio 1.16 [1.11-1.22]