rs3802842
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | normal |
| (A;C) | 1.17 | 1.17x increased risk of colorectal cancer |
| (C;C) | 2 | >1.17x increased risk of colorectal cancer |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 111300984 |
| Gene | COLCA1, COLCA2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3802842 |
| dbSNP (classic) | rs3802842 |
| ClinGen | rs3802842 |
| ebi | rs3802842 |
| HLI | rs3802842 |
| Exac | rs3802842 |
| Gnomad | rs3802842 |
| Varsome | rs3802842 |
| LitVar | rs3802842 |
| Map | rs3802842 |
| PheGenI | rs3802842 |
| Biobank | rs3802842 |
| 1000 genomes | rs3802842 |
| hgdp | rs3802842 |
| ensembl | rs3802842 |
| geneview | rs3802842 |
| scholar | rs3802842 |
| rs3802842 | |
| pharmgkb | rs3802842 |
| gwascentral | rs3802842 |
| openSNP | rs3802842 |
| 23andMe | rs3802842 |
| SNPshot | rs3802842 |
| SNPdbe | rs3802842 |
| MSV3d | rs3802842 |
| GWAS Ctlg | rs3802842 |
| GMAF | 0.3136 |
| Max Magnitude | 2 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
rs3802842 is a SNP in a region of ch 11q23.1 that has been associated with some cancers.
IN a study of over 10,000 cases of colorectal cancer, rs3802842(C) was associated with increased risk (odds ratio 1.17, CI: 1.12-1.22, p = 1.08 x 10e-12). Additional SNPs in chromosomal regions 8q21, 8q24, 10p14, 11q, 15q13.3 and 18q21 can be combined additively to produce an overall risk, with an average odds ratio per risk allele of 1.19.[PMID 18753146]
| GWAS | |
|---|---|
| SNP | rs3802842 |
| PubMedID | [PMID 18372901 ]
|
| Condition | Colorectal cancer |
| Gene | Intergenic |
| Risk Allele | C |
| pValue | 6.00E-010 |
| OR | 1.11 |
| 95% CI | 1.08-1.15 |
[PMID 19843678] Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort
[PMID 20530476] Risk of Genome-Wide Association Study-Identified Genetic Variants for Colorectal Cancer in a Chinese Population
[PMID 20659471] Genetic Heterogeneity in Colorectal Cancer Associations in Americans of African vs. European Descent
[PMID 21097774] Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome
[PMID 21119214] Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters
| GWAS snp | |
|---|---|
| PMID | [PMID 21761138]
|
| Trait | |
| Title | Meta-analysis of new genome-wide association studies of colorectal cancer risk. |
| Risk Allele | |
| P-val | 4E-7 |
| Odds Ratio | 1.1400 [1.08-1.20] |
[PMID 22367214] Characterization of gene-environment interactions for colorectal cancer susceptibility loci
[PMID 22457859] Single nucleotide polymorphisms in colorectal cancer: associations with tumor site and TNM stage
[PMID 19010329] Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.
[PMID 19011631] Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
[PMID 20501757] Low-penetrance susceptibility variants in familial colorectal cancer.
[PMID 20648012] Association studies on 11 published colorectal cancer risk loci.
[PMID 21071539] Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.
[PMID 21314996] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.
[PMID 22045029] Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.
[PMID 22235025] Susceptibility genetic variants associated with early-onset colorectal cancer.
[PMID 23029024] Replication Study in Chinese Population and Meta-Analysis Supports Association of the 11q23 Locus with Colorectal Cancer
[PMID 23359760] Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population
| GWAS snp | |
|---|---|
| PMID | [PMID 23266556]
|
| Trait | Colorectal cancer |
| Title | Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-wide Meta-analysis. |
| Risk Allele | |
| P-val | 4E-7 |
| Odds Ratio | 1.11 [1.06-1.15] |
[PMID 24256810] Identification and Characterization of Functional Risk Variants for Colorectal Cancer Mapping to Chromosome 11q23.1
[PMID 22848671] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
[PMID 22987364] Combined analysis of three Lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers.
[PMID 22999960] Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
[PMID 23434150] Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?
[PMID 24801760] Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP
| GWAS snp | |
|---|---|
| PMID | [PMID 24836286]
|
| Trait | Colorectal cancer |
| Title | Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. |
| Risk Allele | C |
| P-val | 3E-7 |
| Odds Ratio | 1.09 [1.05-1.12] |
[PMID 26078566] Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population
