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rs3802842

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;C) 1.17 1.17x increased risk of colorectal cancer
(C;C) 2 >1.17x increased risk of colorectal cancer
ReferenceGRCh38 38.1/141
Chromosome11
Position111300984
GeneC11orf92, C11orf93
is asnp
is mentioned by
dbSNPrs3802842
ebirs3802842
HLIrs3802842
Exacrs3802842
Varsomers3802842
Maprs3802842
PheGenIrs3802842
hapmaprs3802842
1000 genomesrs3802842
hgdprs3802842
ensemblrs3802842
gopubmedrs3802842
geneviewrs3802842
scholarrs3802842
googlers3802842
pharmgkbrs3802842
gwascentralrs3802842
openSNPrs3802842
23andMers3802842
23andMe allrs3802842
SNP Nexus

SNPshotrs3802842
SNPdbers3802842
MSV3drs3802842
GWAS Ctlgrs3802842
GMAF0.3136
Max Magnitude2
? (A;A) (A;C) (C;C) 28
rs3802842 is a SNP in a region of ch 11q23.1 that has been associated with some cancers.

IN a study of over 10,000 cases of colorectal cancer, rs3802842(C) was associated with increased risk (odds ratio 1.17, CI: 1.12-1.22, p = 1.08 x 10e-12). Additional SNPs in chromosomal regions 8q21, 8q24, 10p14, 11q, 15q13.3 and 18q21 can be combined additively to produce an overall risk, with an average odds ratio per risk allele of 1.19.[PMID 18753146]

GWAS
SNP rs3802842
PubMedID [PMID 18372901OA-icon.png]
Condition Colorectal cancer
Gene Intergenic
Risk Allele C
pValue 6.00E-010
OR 1.11
95% CI 1.08-1.15


OMIM612232
DescCOLORECTAL CANCER, SUSCEPTIBILITY TO, 7; CRCS7
Variant
Relatedalso

[PMID 19843678] Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort



[PMID 20530476] Risk of Genome-Wide Association Study-Identified Genetic Variants for Colorectal Cancer in a Chinese Population

[PMID 20659471OA-icon.png] Genetic Heterogeneity in Colorectal Cancer Associations in Americans of African vs. European Descent

[PMID 21097774] Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome

[PMID 21119214OA-icon.png] Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters

GWAS snp
PMID [PMID 21761138OA-icon.png]
Trait
Title Meta-analysis of new genome-wide association studies of colorectal cancer risk.
Risk Allele
P-val 4E-7
Odds Ratio 1.1400 [1.08-1.20]


[PMID 22367214OA-icon.png] Characterization of gene-environment interactions for colorectal cancer susceptibility loci


[PMID 22457859] Single nucleotide polymorphisms in colorectal cancer: associations with tumor site and TNM stage


[PMID 19010329] Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.


[PMID 19011631OA-icon.png] Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.


[PMID 20501757OA-icon.png] Low-penetrance susceptibility variants in familial colorectal cancer.


[PMID 20648012OA-icon.png] Association studies on 11 published colorectal cancer risk loci.


[PMID 21071539OA-icon.png] Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.


[PMID 21314996OA-icon.png] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.


[PMID 22045029] Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.


[PMID 22235025] Susceptibility genetic variants associated with early-onset colorectal cancer.


[PMID 23029024OA-icon.png] Replication Study in Chinese Population and Meta-Analysis Supports Association of the 11q23 Locus with Colorectal Cancer


GET Evidence
rs3802842
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.58871
summary



[PMID 23359760OA-icon.png] Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population

GWAS snp
PMID [PMID 23266556OA-icon.png]
Trait Colorectal cancer
Title Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-wide Meta-analysis.
Risk Allele
P-val 4E-7
Odds Ratio 1.11 [1.06-1.15]


[PMID 24256810OA-icon.png] Identification and Characterization of Functional Risk Variants for Colorectal Cancer Mapping to Chromosome 11q23.1


[PMID 22848671OA-icon.png] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.


[PMID 22987364] Combined analysis of three Lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers.


[PMID 22999960OA-icon.png] Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.


[PMID 23434150OA-icon.png] Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?


[PMID 24801760OA-icon.png] Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP

GWAS snp
PMID [PMID 24836286OA-icon.png]
Trait Colorectal cancer
Title Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Risk Allele C
P-val 3E-7
Odds Ratio 1.09 [1.05-1.12]


[PMID 26078566OA-icon.png] Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population