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rs3807306

From SNPedia

Orientationminus
Stabilizedminus
Make rs3807306(A;A)
Make rs3807306(A;C)
Make rs3807306(C;C)
ReferenceGRCh38 38.1/141
Chromosome7
Position128940626
GeneIRF5
is asnp
is mentioned by
dbSNPrs3807306
ebirs3807306
HLIrs3807306
Exacrs3807306
Varsomers3807306
Maprs3807306
PheGenIrs3807306
hapmaprs3807306
1000 genomesrs3807306
hgdprs3807306
ensemblrs3807306
gopubmedrs3807306
geneviewrs3807306
scholarrs3807306
googlers3807306
pharmgkbrs3807306
gwascentralrs3807306
openSNPrs3807306
23andMers3807306
23andMe allrs3807306
SNP Nexus

SNPshotrs3807306
SNPdbers3807306
MSV3drs3807306
GWAS Ctlgrs3807306
GMAF0.3494
Max Magnitude
? (A;A) (A;C) (C;C) 28
[PMID 18285424OA-icon.png] rs4728142, rs3807306 and a 5 bp insertion-deletion linked multiple sclerosis in three populations

[PMID 18288123] Associated with systemic lupus erythematosus (SLE) in African Americans.

OMIM180300
DescRHEUMATOID ARTHRITIS; RA
Variant
Relatedalso
OMIM607218
DescINTERFERON REGULATORY FACTOR 5; IRF5
Variant
Relatedalso
[PMID 15657875OA-icon.png] Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.


[PMID 17189288OA-icon.png] Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation.


[PMID 18668568OA-icon.png] Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients.


[PMID 19109131OA-icon.png] Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.


[PMID 19956648OA-icon.png] Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases.


[PMID 20479942OA-icon.png] Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.


[PMID 20603721OA-icon.png] Genome-wide association filtering using a highly locus-specific transmission/disequilibrium test.


[PMID 20861862] Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection.


[PMID 23971939] IRF5, but not TLR4, DEFEB1, or VDR, is associated with the risk of ulcerative colitis in a Han Chinese population

GWAS snp
PMID [PMID 21156761OA-icon.png]
Trait Rheumatoid arthritis
Title A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
Risk Allele
P-val 3E-7
Odds Ratio 1.44 [1.25-1.66]


[PMID 25564941] Association between genetic polymorphisms in Interferon Regulatory Factor 5 (IRF5) gene and Malaysian patients with Crohn's disease