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rs3813929

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 possible weight gain if taking olanzapine
(C;T) normal
(T;T) normal
ReferenceGRCh38 38.1/141
ChromosomeX
Position114584047
GeneHTR2C
is asnp
is mentioned by
dbSNPrs3813929
ebirs3813929
HLIrs3813929
Exacrs3813929
Varsomers3813929
Maprs3813929
PheGenIrs3813929
hapmaprs3813929
1000 genomesrs3813929
hgdprs3813929
ensemblrs3813929
gopubmedrs3813929
geneviewrs3813929
scholarrs3813929
googlers3813929
pharmgkbrs3813929
gwascentralrs3813929
openSNPrs3813929
23andMers3813929
23andMe allrs3813929
SNP Nexus

SNPshotrs3813929
SNPdbers3813929
MSV3drs3813929
GWAS Ctlgrs3813929
GMAF0.1167
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs3813929, also known as -759C/T, is a SNP in the 5-hydroxytryptamine (serotonin) receptor 2C HTR2C gene.

A study of 107 patients with schizophrenia being treated with olanzapine reported a protective effect against weight-gain from the (T) allele of this SNP; zero patients (of 28) with a rs3813929(T) allele had a body mass index increase of >=10% (p=0.002), whereas (C;C) homozygotes did. This effect may also involve nearby SNP rs518147.[PMID 19434072]

[PMID 20065966] T allele showed borderline significant association with higher BMI and incidence of lifetime major depressive disorder among 4978 persons from the European Prospective Investigation into Cancer (EPIC)-Norfolk study, however, only the association with BMI remained borderline significant within the full EPIC-Norfolk cohort (20,981 persons)

[PMID 19416518OA-icon.png] Investigation of the serotonin 2C receptor gene in attention deficit hyperactivity disorder in UK samples



[PMID 19690620OA-icon.png] Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes

[PMID 20092861] Further exploration of the possible influence of polymorphisms in HTR2C and 5HTT on body weight


[PMID 20562674] Association between LEP and LEPR gene polymorphisms and dyslipidemia in patients using atypical antipsychotic medication

[PMID 20680028] Association between HTR2C gene polymorphisms and the metabolic syndrome in patients using antipsychotics: a replication study

[PMID 20504252] Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample




[PMID 21510767] Polymorphisms of the LEP-, LEPR and HTR2C gene: obesity and BMI change in patients using antipsychotic medication in a naturalistic setting

[PMID 17016522] The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study.

[PMID 17291373] Association of the HTR2C gene and antipsychotic induced weight gain: a meta-analysis.

[PMID 17632216] The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia.

[PMID 18081710OA-icon.png] Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.

[PMID 18802918] Focus on HTR2C: A possible suggestion for genetic studies of complex disorders.

[PMID 19142101] HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia: a replication study.

[PMID 19359258OA-icon.png] Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.

[PMID 20060656] Association of polymorphisms of the serotonergic system with smoking initiation in Caucasians.

[PMID 21162693OA-icon.png] Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.

[PMID 21391883] Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gain.


GET Evidence
rs3813929
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0978261
summary



[PMID 23499153] Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy


[PMID 22914617] Analysis of the BTBD9 and HTR2C variants in Chinese Han patients with Tourette syndrome.


ClinVar
Risk rs3813929(T;T)
Alt rs3813929(T;T)
Reference rs3813929(C;C)
Significance Drug-response
Disease olanzapine response - Toxicity/ADR
Variation info
Gene HTR2C
CLNDBN olanzapine response - Toxicity/ADR
Reversed 0
HGVS NC_000023.10:g.113818520C>T
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211364.1,