| Geno
|
Mag
|
Summary
|
| (C;C)
|
1
|
Normal risk of developing Crohn's disease
|
| (C;T)
|
1.5
|
1.3x increased risk for Crohn's disease with ileal involvement
|
| (T;T)
|
1.5
|
1.3x increased risk for Crohn's disease with ileal involvement
|
rs3814570 is a SNP in the transcription factor 7-like 2 (T-cell specific, HMG-box) TCF7L2 gene.
A study of 784 Crohn's disease patients with ileal involvement concluded that rs3814570 was associated with increased risk, but not with risk for colonic Crohn's disease or ulcerative colitis. The odds ratio was 1.27 (CI: 1.07 - 1.52, p = 0.00737).[PMID 19221600
]
[PMID 19351735] Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2.
]
