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rs3816587

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1.3x risk
(C;T) 0 normal
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome4
Position25415622
GeneANAPC4
is asnp
is mentioned by
dbSNPrs3816587
ebirs3816587
HLIrs3816587
Exacrs3816587
Varsomers3816587
Maprs3816587
PheGenIrs3816587
hapmaprs3816587
1000 genomesrs3816587
hgdprs3816587
ensemblrs3816587
gopubmedrs3816587
geneviewrs3816587
scholarrs3816587
googlers3816587
pharmgkbrs3816587
gwascentralrs3816587
openSNPrs3816587
23andMers3816587
23andMe allrs3816587
SNP Nexus

SNPshotrs3816587
SNPdbers3816587
MSV3drs3816587
GWAS Ctlgrs3816587
GMAF0.4683
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs3816587 has been reported in a large study to be associated with rheumatoid arthritis.

The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 0.91 (CI 0.80-1.04), and for homozygotes, 1.35 (CI 1.14-1.59). [PMID 17554300OA-icon.png]

GWAS
SNP rs3816587
PubMedID [PMID 17554300OA-icon.png]
Condition Rheumatoid arthritis
Gene NR
Risk Allele C
pValue 9.00E-006
OR 1.09
95% CI 0.96-1.25



[PMID 18794857OA-icon.png] Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.


[PMID 20017963OA-icon.png] Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis.


GET Evidence
rs3816587
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.523438
summary