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rs3818361

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 normal
(C;T) 1.1 1.15x increased risk for late-onset Alzheimer's
(T;T) 1.2 1.2x increased risk for late-onset Alzheimer's
ReferenceGRCh38 38.1/141
Chromosome1
Position207611623
GeneCR1
is asnp
is mentioned by
dbSNPrs3818361
ebirs3818361
HLIrs3818361
Exacrs3818361
Varsomers3818361
Maprs3818361
PheGenIrs3818361
hapmaprs3818361
1000 genomesrs3818361
hgdprs3818361
ensemblrs3818361
gopubmedrs3818361
geneviewrs3818361
scholarrs3818361
googlers3818361
pharmgkbrs3818361
gwascentralrs3818361
openSNPrs3818361
23andMers3818361
23andMe allrs3818361
SNP Nexus

SNPshotrs3818361
SNPdbers3818361
MSV3drs3818361
GWAS Ctlgrs3818361
GMAF0.2691
Max Magnitude1.2
? (C;C) (C;T) (T;T) 28
rs3818361 is a SNP associated with the complement component (3b/4b) receptor 1 CR1 gene.

[PMID 20554627OA-icon.png] The association of this SNP and late-onset Alzheimer's disease was replicated over a total of another 1829 cases (and 2576 controls). The odds ratio for rs3818361(T) allele was 1.15 (note the p value was 0.014).


[PMID 20558149] Complement receptor 1 polymorphisms and risk of late onset Alzheimer's disease

[PMID 20697030OA-icon.png] Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes


[PMID 21321396OA-icon.png] Replication of BIN1 Association with Alzheimer's Disease and Evaluation of Genetic Interactions

GWAS snp
PMID [PMID 21460840OA-icon.png]
Trait
Title Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
Risk Allele
P-val 4E-14
Odds Ratio 1.1800 [1.13-1.24]


[PMID 19734902OA-icon.png] Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.


[PMID 21379329OA-icon.png] Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.


[PMID 21390209OA-icon.png] Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.


[PMID 22244847] Alzheimer's disease risk factor complement receptor 1 is associated with depression.


[PMID 22402018] Implication of common and disease specific variants in CLU, CR1, and PICALM


[PMID 23419238OA-icon.png] Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms


[PMID 22430674OA-icon.png] Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.


[PMID 23022416OA-icon.png] Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype.


[PMID 24998857] CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease


[PMID 27103528] Association of genetic risk factors with cognitive decline: the PATH through life project.