rs3821236

risk of Systemic lupus erythematosus

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(A;A)	2.1	2x higher risk of lupus
(A;G)	2	1.4x higher risk of lupus
(G;G)	0	normal

Reference

GRCh38 38.1/141

Chromosome

2

Position

191038032

Gene

STAT4

is a	snp
is	mentioned by
dbSNP	rs3821236
dbSNP (classic)	rs3821236
ClinGen	rs3821236
ebi	rs3821236
HLI	rs3821236
Exac	rs3821236
Gnomad	rs3821236
Varsome	rs3821236
LitVar	rs3821236
Map	rs3821236
PheGenI	rs3821236
Biobank	rs3821236
1000 genomes	rs3821236
hgdp	rs3821236
ensembl	rs3821236
geneview	rs3821236
scholar	rs3821236
google	rs3821236
pharmgkb	rs3821236
gwascentral	rs3821236
openSNP	rs3821236
23andMe	rs3821236
SNPshot	rs3821236
SNPdbe	rs3821236
MSV3d	rs3821236
GWAS Ctlg	rs3821236

GMAF

0.309

Max Magnitude

2.1

?	(A;A) (A;G) (G;G)	28

GWAS snp
PMID	[PMID 18677312]
Trait	Systemic lupus erythematosus
Title	Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
Risk Allele
P-val	7.9999999999999995E-11
Odds Ratio	1.49 [NR]

CPMC uses this to indicate increased risk of Systemic lupus erythematosus.

[PMID 19644876] Association of STAT4 and BLK, but not BANK1 or IRF5, with primary antiphospholipid syndrome

GWAS snp
PMID	[PMID 19165918]
Trait	Systemic lupus erythematosus
Title	PubMedID=18677312: cannot get document summary
Risk Allele
P-val	7.9999999999999995E-11
Odds Ratio	1.49 [NR]

GWAS snp
PMID	[PMID 20383147]
Trait	Systemic sclerosis
Title	Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
Risk Allele	A
P-val	3E-9
Odds Ratio	1.30 [1.19-1.41]

GWAS snp
PMID	[PMID 21779181]
Trait
Title	Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
Risk Allele
P-val	9E-8
Odds Ratio	1.3100 [1.19-1.48]

[PMID 22440820] IRF5 polymorphism predicts prognosis in patients with systemic sclerosis

[PMID 18516230] Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.

[PMID 18579578] A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.

[PMID 19019891] STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk.

[PMID 19287509] Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis.

[PMID 19333953] High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.

[PMID 20652065] Interferon alpha in systemic lupus erythematosus.

[PMID 20722033] The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.

[PMID 23755762] STAT4 is a genetic risk factor for systemic sclerosis in a Chinese population

[PMID 32973967] SNPs in the interleukin-12 signaling pathway are associated with breast cancer risk in Puerto Rican women.