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rs3846663

From SNPedia

Orientationplus
Stabilizedplus
Make rs3846663(C;C)
Make rs3846663(C;T)
Make rs3846663(T;T)
ReferenceGRCh38 38.1/141
Chromosome5
Position75359901
GeneHMGCR
is asnp
is mentioned by
dbSNPrs3846663
ebirs3846663
HLIrs3846663
Exacrs3846663
Varsomers3846663
Maprs3846663
PheGenIrs3846663
hapmaprs3846663
1000 genomesrs3846663
hgdprs3846663
ensemblrs3846663
gopubmedrs3846663
geneviewrs3846663
scholarrs3846663
googlers3846663
pharmgkbrs3846663
gwascentralrs3846663
openSNPrs3846663
23andMers3846663
23andMe allrs3846663
SNP Nexus

SNPshotrs3846663
SNPdbers3846663
MSV3drs3846663
GWAS Ctlgrs3846663
GMAF0.3976
Max Magnitude
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 19060906OA-icon.png]
Trait LDL cholesterol
Title Common variants at 30 loci contribute to polygenic dyslipidemia
Risk Allele T
P-val 8E-12
Odds Ratio 0.07 [0.03-0.11] SD increase

LDL cholesterol levels being the quantitative trait associated with in [PMID 19197348OA-icon.png]

GWAS snp
PMID [PMID 19197348OA-icon.png]
Trait Quantitative traits
Title Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae
Risk Allele T
P-val 0.000001
Odds Ratio 0.21 [NR] mg/dL increase


[PMID 18802019OA-icon.png] Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.

[PMID 19554360OA-icon.png] The HMG-CoA reductase gene and lipid and lipoprotein levels: the multi-ethnic study of atherosclerosis.

[PMID 19951432OA-icon.png] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

[PMID 20005478OA-icon.png] The role of HMGCR alternative splicing in statin efficacy.


GET Evidence
rs3846663
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.367188
summary