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rs3865418

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal
(C;T) 1.3x increased risk for hypertension
(G;G) 0
(T;T) >1.3x increased risk for hypertension
ReferenceGRCh38 38.1/141
Chromosome18
Position58336932
GeneNEDD4L
is asnp
is mentioned by
dbSNPrs3865418
ebirs3865418
HLIrs3865418
Exacrs3865418
Varsomers3865418
Maprs3865418
PheGenIrs3865418
hapmaprs3865418
1000 genomesrs3865418
hgdprs3865418
ensemblrs3865418
gopubmedrs3865418
geneviewrs3865418
scholarrs3865418
googlers3865418
pharmgkbrs3865418
gwascentralrs3865418
openSNPrs3865418
23andMers3865418
23andMe allrs3865418
SNP Nexus

SNPshotrs3865418
SNPdbers3865418
MSV3drs3865418
GWAS Ctlgrs3865418
GMAF0.4747
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs3865418, a SNP in the NEDD4L gene, has been associated with hypertension in a study of Chinese (Hans) patients.

Association under an additive model yielded an odds ratio of 1.31 (CI: 1.04-1.67, p=0.025) for the rs3865418(T) allele. The association remained significant (p = 0.039) after adjusting for age and sex, and was primarily associated with significantly higher diastolic blood pressure.[PMID 18293164]


[PMID 20003179OA-icon.png] Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study.


[PMID 23549273OA-icon.png] A Functional Variant of NEDD4L Is Associated with Obesity and Related Phenotypes in a Han Population of Southern China.