rs3865418

plus

Geno	Mag	Summary
(C;C)	0	normal
(C;T)		1.3x increased risk for hypertension
(G;G)	0
(T;T)		>1.3x increased risk for hypertension

Reference

GRCh38 38.1/141

Chromosome

18

Position

58336932

Gene

NEDD4L

is a	snp
is	mentioned by
dbSNP	rs3865418
dbSNP (classic)	rs3865418
ClinGen	rs3865418
ebi	rs3865418
HLI	rs3865418
Exac	rs3865418
Gnomad	rs3865418
Varsome	rs3865418
LitVar	rs3865418
Map	rs3865418
PheGenI	rs3865418
Biobank	rs3865418
1000 genomes	rs3865418
hgdp	rs3865418
ensembl	rs3865418
geneview	rs3865418
scholar	rs3865418
google	rs3865418
pharmgkb	rs3865418
gwascentral	rs3865418
openSNP	rs3865418
23andMe	rs3865418
SNPshot	rs3865418
SNPdbe	rs3865418
MSV3d	rs3865418
GWAS Ctlg	rs3865418

GMAF

0.4747

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

rs3865418, a SNP in the NEDD4L gene, has been associated with hypertension in a study of Chinese (Hans) patients.

Association under an additive model yielded an odds ratio of 1.31 (CI: 1.04-1.67, p=0.025) for the rs3865418(T) allele. The association remained significant (p = 0.039) after adjusting for age and sex, and was primarily associated with significantly higher diastolic blood pressure.[PMID 18293164]

[PMID 20003179 ] Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study.

[PMID 23549273 ] A Functional Variant of NEDD4L Is Associated with Obesity and Related Phenotypes in a Han Population of Southern China.