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rs3865444

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(G;G) 0 common/normal
(G;T) 1.5 slight reduction in risk for Alzheimer's disease
(T;T) 1.6 slight reduction in risk for Alzheimer's disease
ReferenceGRCh38 38.1/141
Chromosome19
Position51224706
GeneCD33
is asnp
is mentioned by
dbSNPrs3865444
ebirs3865444
HLIrs3865444
Exacrs3865444
Varsomers3865444
Maprs3865444
PheGenIrs3865444
hapmaprs3865444
1000 genomesrs3865444
hgdprs3865444
ensemblrs3865444
gopubmedrs3865444
geneviewrs3865444
scholarrs3865444
googlers3865444
pharmgkbrs3865444
gwascentralrs3865444
openSNPrs3865444
23andMers3865444
23andMe allrs3865444
SNP Nexus

SNPshotrs3865444
SNPdbers3865444
MSV3drs3865444
GWAS Ctlgrs3865444
GMAF0.2378
Max Magnitude1.6

The less common allele for this SNP, rs3865444(T), is associated with a slight decrease in risk for Alzheimer's disease, on the order of 0.9x (i.e. a 10% decrease in risk). One visualization of such studies is available here on the AlzGene website.

? (G;G) (G;T) (T;T) 28
Alzheimer's disease associated, based on large 2011 study 10.1038/ng.801[PMID 21460841OA-icon.png] Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease


[PMID 22382309] The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer's disease.


[PMID 23623698OA-icon.png] Alzheimer's Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta


[PMID 23946390OA-icon.png] CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing


[PMID 23708142OA-icon.png] CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology


[PMID 23232270] Association of GWAS-linked loci with late-onset Alzheimer's disease in a northern Han Chinese population.

GWAS snp
PMID [PMID 24162737OA-icon.png]
Trait Alzheimer's disease (late onset)
Title Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
Risk Allele C
P-val 3E-6
Odds Ratio 1.06 [1.04-1.1]


[PMID 24788522] Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity


[PMID 25670335] Association of Alzheimer's disease GWAS loci with MRI markers of brain aging


[PMID 25762156] Genetics of CD33 in Alzheimer's Disease and Acute Myeloid Leukemia


[PMID 26455864] Association of CD33 and MS4A cluster variants with Alzheimer's disease in East Asian Populations


[PMID 26680604] Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.