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rs3890745

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 1.12x risk of Rheumatoid arthritis
(A;G)
(G;G) 0 0.79x Reduced risk of RA
ReferenceGRCh38 38.1/141
Chromosome1
Position2622185
GeneMMEL1
is asnp
is mentioned by
dbSNPrs3890745
ebirs3890745
HLIrs3890745
Exacrs3890745
Varsomers3890745
Maprs3890745
PheGenIrs3890745
hapmaprs3890745
1000 genomesrs3890745
hgdprs3890745
ensemblrs3890745
gopubmedrs3890745
geneviewrs3890745
scholarrs3890745
googlers3890745
pharmgkbrs3890745
gwascentralrs3890745
openSNPrs3890745
23andMers3890745
23andMe allrs3890745
SNP Nexus

SNPshotrs3890745
SNPdbers3890745
MSV3drs3890745
GWAS Ctlgrs3890745
GMAF0.4307
Max Magnitude0
? (A;A) (A;G) (G;G) 28
GWAS
SNP rs3890745
PubMedID [PMID 18794853OA-icon.png]
Condition Rheumatoid arthritis
Gene MMEL1-TNFRSF14
Risk Allele T
pValue 1.00E-007
OR 1.12
95% CI


OMIM180300
DescRHEUMATOID ARTHRITIS; RA
Variant
Relatedalso


GWAS snp
PMID [PMID 20453842OA-icon.png]
Trait Rheumatoid arthritis
Title Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lock
Risk Allele T
P-val 0.000004
Odds Ratio 1.12 [1.06-1.18]


[PMID 21784728] Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population


[PMID 22365150OA-icon.png] Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12


[PMID 20007504OA-icon.png] Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci.


[PMID 20426808OA-icon.png] AntEpiSeeker: detecting epistatic interactions for case-control studies using a two-stage ant colony optimization algorithm.


[PMID 20639879OA-icon.png] Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.


[PMID 21383967OA-icon.png] Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.


[PMID 21765104OA-icon.png] Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction.


GET Evidence
rs3890745
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.476562
summary



[PMID 22922229OA-icon.png] Seven newly identified loci for autoimmune thyroid disease.

GWAS snp
PMID [PMID 24449572OA-icon.png]
Trait Rheumatoid arthritis
Title Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
Risk Allele
P-val 1E-6
Odds Ratio 1.18 [1.1-1.27]