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rs402710

From SNPedia

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Geno Mag Summary
(C;C) 1.9 Common, but higher lung cancer risk ?
Make rs402710(C;T)
Make rs402710(T;T)
ReferenceGRCh38 38.1/141
Chromosome5
Position1320607
GeneCLPTM1L
is asnp
is mentioned by
dbSNPrs402710
ebirs402710
HLIrs402710
Exacrs402710
Varsomers402710
Maprs402710
PheGenIrs402710
hapmaprs402710
1000 genomesrs402710
hgdprs402710
ensemblrs402710
gopubmedrs402710
geneviewrs402710
scholarrs402710
googlers402710
pharmgkbrs402710
gwascentralrs402710
openSNPrs402710
23andMers402710
23andMe allrs402710
SNP Nexus

SNPshotrs402710
SNPdbers402710
MSV3drs402710
GWAS Ctlgrs402710
GMAF0.3618
Max Magnitude1.9
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 18978790OA-icon.png]
Trait Lung cancer
Title Lung cancer susceptibility locus at 5p15.33
Risk Allele C
P-val 0.000004
Odds Ratio 1.18 [1.12-1.24]


[PMID 19465454] The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung

OMIM612571
DescLUNG CANCER SUSCEPTIBILITY 3; LNCR3
Variant
Relatedalso
[PMID 20056643OA-icon.png] A rigorous and comprehensive validation: common genetic variations and lung cancer


[PMID 21750227] Single-nucleotide polymorphisms (5p15.33, 15q25.1, 6p22.1, 6q27 and 7p15.3) and lung cancer survival in the European Prospective Investigation into Cancer and Nutrition (EPIC)


[PMID 22404340] Replication of results of genome-wide association studies on lung cancer susceptibility loci in a Korean population


[PMID 22653581] A common genetic variant of 5p15.33 is associated with risk for prostate cancer in the Chinese population


[PMID 21966413OA-icon.png] Smoking related cancers and loci at chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish population


[PMID 19369581] Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population.


[PMID 19654303OA-icon.png] Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.


[PMID 19836008OA-icon.png] A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.


[PMID 20101243OA-icon.png] A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.


[PMID 20548021OA-icon.png] Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium.


[PMID 20628624OA-icon.png] Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".


[PMID 20700438OA-icon.png] The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia.


[PMID 21081471OA-icon.png] Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study.


[PMID 21304900OA-icon.png] Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD.


[PMID 22228261] Common genetic variants in TERT contribute to risk of cervical cancer in a Chinese population.


[PMID 22370939] Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma.


[PMID 22523397OA-icon.png] Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis.


GET Evidence
rs402710
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.368387
summary



[PMID 24194831OA-icon.png] The SNP rs402710 in 5p15.33 Is Associated with Lung Cancer Risk: A Replication Study in Chinese Population and a Meta-Analysis


[PMID 23085811] Tobacco consumption and genetic susceptibility to nasopharyngeal carcinoma (NPC) in Thailand.


[PMID 24907075] Association between CLPTM1L polymorphisms (rs402710 and rs401681) and lung cancer susceptibility: evidence from 27 case-control studies


[PMID 24615522] Quantitative assessment of common genetic variants on chromosome 5p15 and lung cancer risk


[PMID 25155038] Correlation of CLPTM1L polymorphisms with lung cancer susceptibility and response to cisplatin-based chemotherapy in a Chinese Han population