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rs405509

From SNPedia

Orientationminus
Stabilizedplus
Make rs405509(A;A)
Make rs405509(A;C)
Make rs405509(C;C)
ReferenceGRCh38 38.1/142
Chromosome19
Position44905579
GeneAPOE
is asnp
is mentioned by
dbSNPrs405509
ebirs405509
HLIrs405509
Exacrs405509
Varsomers405509
Maprs405509
PheGenIrs405509
hapmaprs405509
1000 genomesrs405509
hgdprs405509
ensemblrs405509
gopubmedrs405509
geneviewrs405509
scholarrs405509
googlers405509
pharmgkbrs405509
gwascentralrs405509
openSNPrs405509
23andMers405509
23andMe allrs405509
SNP Nexus

SNPshotrs405509
SNPdbers405509
MSV3drs405509
GWAS Ctlgrs405509
GMAF0.4931
Max Magnitude
? (A;A) (A;C) (C;C) 28

[PMID 17658295] obstructive sleep apnea rs405509

[PMID 19172988OA-icon.png] Significant Alzheimer's disease associations with were found for rs449647(A;A) and rs405509(G;G) genotypes (positive), and rs449647(A;T) and rs405509(T;T)

Note: the 2016 paper discussing a potential algorithm for Alzheimer's risk based on ApoE promoter polymorphisms, [PMID 27193889OA-icon.png], is considered too preliminary (and based on too few patients) to add to SNPedia in any detail.

Neighborrs440446
Distance331


[PMID 19282863] Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension

[PMID 19384966] Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene


[PMID 19808960OA-icon.png] Apolipoprotein E/C1 Locus Variants Modify Renal Cell Carcinoma Risk



[PMID 21263195] An APOE Haplotype Associated with Decreased ?4 Expression Increases the Risk of Late Onset Alzheimer's Disease

[PMID 21266206] Association of apolipoprotein E promoter polymorphisms with bone structural traits is modified by dietary saturated fat intake - The Cardiovascular Risk in Young Finns Study


[PMID 22028770OA-icon.png] APOE Genotype-Function Relationship: Evidence of -491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk


[PMID 16617143OA-icon.png] Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data.


[PMID 17356695OA-icon.png] Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality.


[PMID 17357073OA-icon.png] Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.


[PMID 17672902OA-icon.png] Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes.


[PMID 18161859OA-icon.png] Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?


[PMID 18254975OA-icon.png] Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.


[PMID 18280754OA-icon.png] Cholesterol-related genetic risk scores are associated with hypometabolism in Alzheimer's-affected brain regions.


[PMID 18813964OA-icon.png] Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.


[PMID 18823527OA-icon.png] A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.


[PMID 19118814OA-icon.png] Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.


[PMID 19327864OA-icon.png] SNPit: a federated data integration system for the purpose of functional SNP annotation.


[PMID 19406964OA-icon.png] Association of genetic variants with chronic kidney disease in Japanese individuals.


[PMID 19408013OA-icon.png] Strategies and issues in the detection of pathway enrichment in genome-wide association studies.


[PMID 19541455] Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients.


[PMID 19668339OA-icon.png] Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.


[PMID 19734902OA-icon.png] Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.


[PMID 20396431OA-icon.png] Genotyping sleep disorders patients.


[PMID 20467002OA-icon.png] Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls.


[PMID 20723945] The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks.


[PMID 21283811OA-icon.png] Associations between APOE variants and metabolic traits and the impact of psychological stress.


[PMID 21882290OA-icon.png] Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies.


GET Evidence
rs405509
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.59322
summary



[PMID 22430674OA-icon.png] Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.


[PMID 23021345] Gene-diet interactions on plasma lipid levels in the Inuit population.


[PMID 23193196OA-icon.png] Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.


[PMID 25085564OA-icon.png] Influence of multiple


ClinVar
Risk rs405509(C;C)
Alt rs405509(C;C)
Reference rs405509(A;A)
Significance Other
Disease Myocardial infarction Coronary artery disease
Variation info
Gene APOE
CLNDBN Myocardial infarction Coronary artery disease, severe, susceptibility to
Reversed 1
HGVS NC_000019.9:g.45408836T\x3d
CLNSRC OMIM Allelic Variant
CLNACC RCV000019463.3, RCV000019464.3,



[PMID 26405973] Gene environment interaction of GALNT2 and APOE gene with hypertension in the Chinese Han Population