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rs4140564

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(T;T) 0 common in complete genomics
Make rs4140564(C;C)
Make rs4140564(C;T)
ReferenceGRCh38 38.1/141
Chromosome1
Position186755871
is asnp
is mentioned by
dbSNPrs4140564
ebirs4140564
HLIrs4140564
Exacrs4140564
Varsomers4140564
Maprs4140564
PheGenIrs4140564
hapmaprs4140564
1000 genomesrs4140564
hgdprs4140564
ensemblrs4140564
gopubmedrs4140564
geneviewrs4140564
scholarrs4140564
googlers4140564
pharmgkbrs4140564
gwascentralrs4140564
openSNPrs4140564
23andMers4140564
23andMe allrs4140564
SNP Nexus

SNPshotrs4140564
SNPdbers4140564
MSV3drs4140564
GWAS Ctlgrs4140564
GMAF0.04408
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs4140564, a SNP on chromosome 1 near the PTGS2 and PLA2G4A genes, has been associated with knee osteoarthritis.

A study of 255 British patients, replicated subsequently in ~2,000 UK, Dutch and US patients, found that rs4140564 was associated with knee osteoarthritis in all populations studied with an overall odds ratio = 1.55, CI: 1.30-1.85, p < 6.9 x 10e-7.[PMID 18471798OA-icon.png]

GWAS
SNP rs4140564
PubMedID [PMID 18471798OA-icon.png]
Condition Knee osteoarthritis
Gene PTGS2, PLA2G4A
Risk Allele
pValue 3.00E-006
OR 1.59
95% CI 1.31-1.94




GET Evidence
rs4140564
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.945312
summary