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rs4146894

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 2.1 9.1x risk for AMD, but replication is lacking
(A;G) 2.6x risk for AMD
(G;G) 0 average
ReferenceGRCh38 38.1/142
Chromosome10
Position122395865
GenePLEKHA1
is asnp
is mentioned by
dbSNPrs4146894
ebirs4146894
HLIrs4146894
Exacrs4146894
Varsomers4146894
Maprs4146894
PheGenIrs4146894
hapmaprs4146894
1000 genomesrs4146894
hgdprs4146894
ensemblrs4146894
gopubmedrs4146894
geneviewrs4146894
scholarrs4146894
googlers4146894
pharmgkbrs4146894
gwascentralrs4146894
openSNPrs4146894
23andMers4146894
23andMe allrs4146894
SNP Nexus

SNPshotrs4146894
SNPdbers4146894
MSV3drs4146894
GWAS Ctlgrs4146894
GMAF0.4991
Max Magnitude2.1
? (A;A) (A;G) (G;G) 28
rs4146894, a SNP in the PLEKHA1 gene, is associated with increased risk for age related macular degeneration based on a study of 118 Caucasians. The odds ratio for risk of AMD was 9.1 (CI: 4.0-20.9, p=0.0001) for the AA genotype and 2.6 (CI: 1.3-5.5, p=0.04) for the AG genotype. The risk is increased further by the status of two other chromosome 10 SNPs, rs10490924 and rs11200638. [PMID 18079691]


[PMID 16080115OA-icon.png] Susceptibility genes for age-related maculopathy on chromosome 10q26.


[PMID 16642439OA-icon.png] Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration.


[PMID 23098369] ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study