|| 9.1x risk for AMD, but replication is lacking
|| 2.6x risk for AMD
|?|| (A;A) (A;G) (G;G) ||28|
, a SNP in the PLEKHA1
gene, is associated with increased risk for age related macular degeneration
based on a study of 118 Caucasians. The odds ratio for risk of AMD was 9.1 (CI: 4.0-20.9, p=0.0001) for the AA genotype and 2.6 (CI: 1.3-5.5, p=0.04) for the AG genotype. The risk is increased further by the status of two other chromosome 10 SNPs, rs10490924
. [PMID 18079691
[PMID 16080115] Susceptibility genes for age-related maculopathy on chromosome 10q26.
[PMID 16642439] Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration.
[PMID 23098369] ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study