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rs419598

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0.29x lower risk for periodontitis
(C;T) 0.29x lower risk for periodontitis
(T;T) normal
ReferenceGRCh38 38.1/141
Chromosome2
Position113129630
GeneIL1RN
is asnp
is mentioned by
dbSNPrs419598
ebirs419598
HLIrs419598
Exacrs419598
Varsomers419598
Maprs419598
PheGenIrs419598
hapmaprs419598
1000 genomesrs419598
hgdprs419598
ensemblrs419598
gopubmedrs419598
geneviewrs419598
scholarrs419598
googlers419598
pharmgkbrs419598
gwascentralrs419598
openSNPrs419598
23andMers419598
23andMe allrs419598
SNP Nexus

SNPshotrs419598
SNPdbers419598
MSV3drs419598
GWAS Ctlgrs419598
GMAF0.1846
Max Magnitude
? (C;C) (C;T) (T;T) 28
May modulate other variations. Also known as the +2018T/C SNP.

In a study of 113 Japanese patients with chronic periodontitis (CP), individuals with the rs419598(C) allele are at 0.29x lower CP risk (p = 0.016).[PMID 18321309]

IL1B -511 allele heterozygotes have a 4 fold higher chance of surviving bacterial meningitis than (either) homozygote [PMID 11023482]. SO what's this have to do with rs419598? Odds of surviving meningitis apparently further increase 2X for IL1B -511 heterozygotes who are also rs419598(T;T), i.e. homozygous for IL1RN +2018 rs419598 (T) allele (the most common one; also known as "+8006").

Neighborrs423904
Distance55


[PMID 19733643] Interleukin-1 region meta-analysis with osteoarthritis phenotypes


[PMID 19290009] Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men

[PMID 20709104] Interleukin 1 receptor antagonist polymorphisms are associated with the risk of developing acute coronary syndrome in Mexicans

[PMID 19934104OA-icon.png] Radiographic severity of knee osteoarthritis is conditional on Interleukin 1 Receptor Antagonist gene variations


[PMID 22322675OA-icon.png] IL1RN genetic variations and risk of IPF: a meta-analysis and mRNA expression study.


[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.


[PMID 16842617OA-icon.png] Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review.


[PMID 17176440] The different expression patterns of interleukin-1 receptor antagonist in systemic lupus erythematosus.


[PMID 17665434OA-icon.png] Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.


[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.


[PMID 18063673] Prospective meta-analysis of interleukin 1 gene complex polymorphisms confirms associations with ankylosing spondylitis.


[PMID 18615156OA-icon.png] Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.


[PMID 19043479OA-icon.png] Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.


[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.


[PMID 20463618OA-icon.png] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.


[PMID 20975573] Interleukin 1 beta (IL-1B) and IL-1 antagonist receptor (IL-1RN) gene polymorphisms are associated with the genetic susceptibility and steroid dependence in patients with ulcerative colitis.


[PMID 21146623] Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis.


[PMID 21279638] Coding single-nucleotide polymorphisms of interleukin-1 gene cluster are not associated with Kawasaki disease in the Korean population.


[PMID 22035161] Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations.


[PMID 23192617] IL-1RN +2018T>C polymorphism is correlated with colorectal cancer


[PMID 23212299] Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth


[PMID 23765978] Association between IL-1RN gene polymorphisms and susceptibility to ankylosing spondylitis: a large Human Genome Epidemiology review and meta-analysis


[PMID 23602982OA-icon.png] IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort


[PMID 22925444] Genetic and immunological markers predict titanium implant failure: a retrospective study.


[PMID 23459936OA-icon.png] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.


[PMID 24008079OA-icon.png] Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts


[PMID 25865535] Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia


[PMID 25398456] IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation


[PMID 26391153] Polymorphisms in host immune response associated genes and risk of nasopharyngeal carcinoma development in Portugal


[PMID 27476361] Genetic and clinical risk factors of root resorption associated with orthodontic treatment.