|(C;C)||0.29x lower risk for periodontitis|
|(C;T)||0.29x lower risk for periodontitis|
In a study of 113 Japanese patients with chronic periodontitis (CP), individuals with the rs419598(C) allele are at 0.29x lower CP risk (p = 0.016).[PMID 18321309]
IL1B -511 allele heterozygotes have a 4 fold higher chance of surviving bacterial meningitis than (either) homozygote [PMID 11023482]. SO what's this have to do with rs419598? Odds of surviving meningitis apparently further increase 2X for IL1B -511 heterozygotes who are also rs419598(T;T), i.e. homozygous for IL1RN +2018 rs419598 (T) allele (the most common one; also known as "+8006").[PMID 19733643] Interleukin-1 region meta-analysis with osteoarthritis phenotypes
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