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rs4254535

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(T;T) 0 common in complete genomics
Make rs4254535(C;C)
Make rs4254535(C;T)
ReferenceGRCh38 38.1/141
Chromosome2
Position68971256
is asnp
is mentioned by
dbSNPrs4254535
ebirs4254535
HLIrs4254535
Exacrs4254535
Varsomers4254535
Maprs4254535
PheGenIrs4254535
hapmaprs4254535
1000 genomesrs4254535
hgdprs4254535
ensemblrs4254535
gopubmedrs4254535
geneviewrs4254535
scholarrs4254535
googlers4254535
pharmgkbrs4254535
gwascentralrs4254535
openSNPrs4254535
23andMers4254535
23andMe allrs4254535
SNP Nexus

SNPshotrs4254535
SNPdbers4254535
MSV3drs4254535
GWAS Ctlgrs4254535
GMAF0.2952
Max Magnitude0
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 19654303OA-icon.png]
Trait Lung cancer
Title Deciphering the Impact of Common Genetic Variation on Lung Cancer Risk: A Genome-Wide Association Study
Risk Allele
P-val 0.000005
Odds Ratio 1.12 [NR]

[PMID 21303977OA-icon.png] Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk.


[PMID 21303977OA-icon.png] Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk.

In this study, we sought to confirm 7 variants with suggestive association to lung cancer (P < 10(-5)) in a recently published meta-analysis. In a GWA dataset of 1,447 lung cancer cases and 36,256 controls in Iceland, 3 correlated variants on 15q15.2 (rs504417, rs11853991, and rs748404) showed a significant association with lung cancer, whereas rs4254535 on 2p14, rs1530057 on 3p24.1, rs6438347 on 3q13.31, and rs1926203 on 10q23.31 did not.


GET Evidence
rs4254535
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.34375
summary