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rs4273077(A;G)

From SNPedia

Possibly slight 1.09x risk for development of MGUS
Is agenotype
ofrs4273077
GeneTNFRSF13B
Chromosome17
Position16,945,825
mentionedby
Magnitude1
ReputeBad
Geno Mag Summary
(A;A) 1 Normal risk for development of MGUS
(A;G) 1 Possibly slight 1.09x risk for development of MGUS
(G;G) 2 3.57x increased risk of MGUS

Very slightly increased risk for the development of MGUS (Monoclonal Gammopathy of Uncertain Significance). 95% CI .78-1.51. Plausible as the homozygote is more statistically significant and higher risk in the same study. Thus, the major, protective A allele can probably be thought of as acting in a dominant fashion in reducing risk of the development of MGUS. This genotype may be benign - any additional risk conferred is likely minimal.