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rs4273077(G;G)

From SNPedia

3.57x increased risk of MGUS
Is agenotype
ofrs4273077
GeneTNFRSF13B
Chromosome17
Position16,945,825
mentionedby
Magnitude2
ReputeBad
Geno Mag Summary
(A;A) 1 Normal risk for development of MGUS
(A;G) 1 Possibly slight 1.09x risk for development of MGUS
(G;G) 2 3.57x increased risk of MGUS

This genotype confers an increased risk of the development of MGUS (Monoclonal Gammopathy of Uncertain Significance). OR=3.57 95% CI=1.67-7.65. The G allele is the minor allele and the risk allele, and appears to function in a recessive manner in increasing risk, as the AG heterozygote has nearly the same risk as the AA homozygote.