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rs4299376

From SNPedia

Orientationplus
Stabilizedplus
Make rs4299376(G;G)
Make rs4299376(G;T)
Make rs4299376(T;T)
ReferenceGRCh38 38.1/141
Chromosome2
Position43845437
GeneABCG8
is asnp
is mentioned by
dbSNPrs4299376
ebirs4299376
HLIrs4299376
Exacrs4299376
Varsomers4299376
Maprs4299376
PheGenIrs4299376
hapmaprs4299376
1000 genomesrs4299376
hgdprs4299376
ensemblrs4299376
gopubmedrs4299376
geneviewrs4299376
scholarrs4299376
googlers4299376
pharmgkbrs4299376
gwascentralrs4299376
openSNPrs4299376
23andMers4299376
23andMe allrs4299376
SNP Nexus

SNPshotrs4299376
SNPdbers4299376
MSV3drs4299376
GWAS Ctlgrs4299376
GMAF0.1726
Max Magnitude
? (G;G) (G;T) (T;T) 28
GWAS snp
PMID [PMID 20686565OA-icon.png]
Trait
Title Biological, clinical and population relevance of 95 loci for blood lipids.
Risk Allele G
P-val 0
Odds Ratio 2.7500 None


[PMID 19060906OA-icon.png] Common variants at 30 loci contribute to polygenic dyslipidemia.


[PMID 19913121OA-icon.png] Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.


GET Evidence
rs4299376
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.761905
summary



[PMID 23707316] High intestinal cholesterol absorption is associated with cardiovascular disease and risk alleles in ABCG8 and ABO: evidence from the LURIC and YFS cohorts and from a meta-analysis


[PMID 23100282OA-icon.png] Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.

GWAS snp
PMID [PMID 24097068OA-icon.png]
Trait Cholesterol, total
Title Discovery and refinement of loci associated with lipid levels.
Risk Allele G
P-val 3E-73
Odds Ratio .08 [NR] unit increase


[PMID 25920552] Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array

GWAS snp
PMID [PMID 19936222OA-icon.png]
Trait Lipid metabolism phenotypes
Title Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
Risk Allele
P-val 2E-8
Odds Ratio 2.60 [NR] unit increase