|| 0.87x decreased risk for ovarian cancer
|| 0.74x decreased risk for ovarian cancer
|?|| (A;A) (A;G) (G;G) ||28|
is a SNP in the IF2
insulin-like growth factor 2 gene.
A study totaling ~5,000 non-Hispanic white patients with ovarian cancer found a 13% decreased risk of ovarian cancer per copy of the rs4320932(G) allele carried (CI: 0.81-0.93, P-trend=7.4 × 10e-5).[PMID 21422097]
Associated with schizophrenia in a study of Croatians. Due to the limited number (~100 patients) and diversity of the studied population, more study is needed to confirm any link. The G allele was associated with an increased risk of schizophrenia with P < 0.001.[PMID 19673036]
Small size study [PMID 23677070] with 212 cases linked the G allele earlier found protective against ovarian cancer increasing relapse by 3.05 (95% confidence interval CI: 1.47–6.37, P-trend 2*10e-4) and mortality 3.28 (95% CI: 1.64–6.57, P-trend 6*10e-5).
[PMID 17980034] Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool 'CubeX'.
[PMID 19673036] Association of Tagging Single Nucleotide Polymorphisms on 8 Candidate Genes in Dopaminergic Pathway with Schizophrenia in Croatian Population
[PMID 19956101] Overview of the Rapid Response data.
|| [PMID 21422097]
|| Ovarian cancer
|| Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk.
| Risk Allele
| Odds Ratio
|| 0.87 [0.81-0.93]
[PMID 22113349] Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.
[PMID 22567146] Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes
[PMID 23677070] An Insulin-like Growth Factor-II Intronic Variant Affects Local DNA Conformation and Ovarian Cancer Survival