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rs4320932

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 normal
(A;G) 1.2 0.87x decreased risk for ovarian cancer
(G;G) 1.4 0.74x decreased risk for ovarian cancer
ReferenceGRCh38 38.1/141
Chromosome11
Position2150371
GeneIGF2, INS-IGF2
is asnp
is mentioned by
dbSNPrs4320932
ebirs4320932
HLIrs4320932
Exacrs4320932
Varsomers4320932
Maprs4320932
PheGenIrs4320932
hapmaprs4320932
1000 genomesrs4320932
hgdprs4320932
ensemblrs4320932
gopubmedrs4320932
geneviewrs4320932
scholarrs4320932
googlers4320932
pharmgkbrs4320932
gwascentralrs4320932
openSNPrs4320932
23andMers4320932
23andMe allrs4320932
SNP Nexus

SNPshotrs4320932
SNPdbers4320932
MSV3drs4320932
GWAS Ctlgrs4320932
GMAF0.258
Max Magnitude1.4
? (A;A) (A;G) (G;G) 28
rs4320932 is a SNP in the IF2 insulin-like growth factor 2 gene.

A study totaling ~5,000 non-Hispanic white patients with ovarian cancer found a 13% decreased risk of ovarian cancer per copy of the rs4320932(G) allele carried (CI: 0.81-0.93, P-trend=7.4 × 10e-5).[PMID 21422097OA-icon.png]

Associated with schizophrenia in a study of Croatians. Due to the limited number (~100 patients) and diversity of the studied population, more study is needed to confirm any link. The G allele was associated with an increased risk of schizophrenia with P < 0.001.[PMID 19673036OA-icon.png]

Small size study [PMID 23677070] with 212 cases linked the G allele earlier found protective against ovarian cancer increasing relapse by 3.05 (95% confidence interval CI: 1.47–6.37, P-trend 2*10e-4) and mortality 3.28 (95% CI: 1.64–6.57, P-trend 6*10e-5).


[PMID 17980034OA-icon.png] Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool 'CubeX'.

[PMID 19673036OA-icon.png] Association of Tagging Single Nucleotide Polymorphisms on 8 Candidate Genes in Dopaminergic Pathway with Schizophrenia in Croatian Population


[PMID 19956101OA-icon.png] Overview of the Rapid Response data.

GWAS snp
PMID [PMID 21422097OA-icon.png]
Trait Ovarian cancer
Title Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk.
Risk Allele G
P-val 7.4E-5
Odds Ratio 0.87 [0.81-0.93]


[PMID 22113349OA-icon.png] Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.


[PMID 22567146OA-icon.png] Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes


[PMID 23677070] An Insulin-like Growth Factor-II Intronic Variant Affects Local DNA Conformation and Ovarian Cancer Survival