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rs4344

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) faster responder
(A;G) slower responder
(G;G) faster responder
ReferenceGRCh38 38.1/141
Chromosome17
Position63489363
GeneACE
is asnp
is mentioned by
dbSNPrs4344
ebirs4344
HLIrs4344
Exacrs4344
Varsomers4344
Maprs4344
PheGenIrs4344
hapmaprs4344
1000 genomesrs4344
hgdprs4344
ensemblrs4344
gopubmedrs4344
geneviewrs4344
scholarrs4344
googlers4344
pharmgkbrs4344
gwascentralrs4344
openSNPrs4344
23andMers4344
23andMe allrs4344
SNP Nexus

SNPshotrs4344
SNPdbers4344
MSV3drs4344
GWAS Ctlgrs4344
GMAF0.4853
Max Magnitude
? (A;A) (A;G) (G;G) 28
This SNP in the ACE gene, also known as G12269A, is reported to influence how quickly African Americans respond to the anti-hypertensive drug ramipril. rs4344(A;A) and rs4344(G;G) homozygotes are able to reach lower blood pressure levels upon treatment with ramipril sooner than rs4344(A;G) heterozygotes. The odds ratio reported for this study, comparing both homozygotes to heterozygotes, is 1.86 (CI: 1.32-3.23). [PMID 17885551OA-icon.png]

Note that this SNP is in almost complete linkage disequilibrium with the insertion/deletion ACE gene SNP.

Neighborrs4646994
Distance824
[PMID 18194558OA-icon.png] A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.


[PMID 19963597OA-icon.png] Visual exploration of genetic association with voxel-based imaging phenotypes in an MCI/AD study.


[PMID 20215856OA-icon.png] Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head.


[PMID 21052031] Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.