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rs4355801

From SNPedia

Increased risk with A allele
Orientationplus
Stabilizedplus
Make rs4355801(A;A)
Make rs4355801(A;G)
Make rs4355801(G;G)
ReferenceGRCh38 38.1/141
Chromosome8
Position118911634
is asnp
is mentioned by
dbSNPrs4355801
ebirs4355801
HLIrs4355801
Exacrs4355801
Varsomers4355801
Maprs4355801
PheGenIrs4355801
hapmaprs4355801
1000 genomesrs4355801
hgdprs4355801
ensemblrs4355801
gopubmedrs4355801
geneviewrs4355801
scholarrs4355801
googlers4355801
pharmgkbrs4355801
gwascentralrs4355801
openSNPrs4355801
23andMers4355801
23andMe allrs4355801
SNP Nexus

SNPshotrs4355801
SNPdbers4355801
MSV3drs4355801
GWAS Ctlgrs4355801
GMAF0.3039
Max Magnitude
? (A;A) (A;G) (G;G) 28
news rs4355801, was associated with a 20% increased risk of osteoporosis (significant at P=0.038).

At least one copy of the risk allele (A) of rs4355801 was found in 79% of study participants.

Participants carrying at least one copy of each risk allele -- 22% of the study population -- had a 50% increased risk of osteoporosis, which was significant at P=0.0026, and a 29% increased risk of osteoporotic fractures (significant at P=0.014).

[PMID 18455228OA-icon.png] rs3736228 associated with decreased bone mineral density (p=6.3x10(-12) for lumbar spine and p=1.9x10(-4) for femoral neck) and an increased risk of both osteoporotic fractures (odds ratio [OR] 1.3, 95% CI 1.09-1.52, p=0.002) and osteoporosis (OR 1.3, 1.08-1.63, p=0.008).

rs4355801 associated with decreased bone mineral density (p=7.6x10(-10) for lumbar spine and p=3.3x10(-8) for femoral neck) and increased risk of osteoporosis (OR 1.2, 95% CI 1.01-1.42, p=0.038).

The presence of both risk alleles increased the risk of osteoporotic fractures (OR 1.3, 1.08-1.63, p=0.006) and this effect was independent of bone mineral density

GWAS
SNP rs4355801
PubMedID [PMID 18455228OA-icon.png]
Condition Bone mineral density
Gene TNFRSF11B
Risk Allele A
pValue 8.00E-010
OR 0.09
95% CI NR) SD decreas



[PMID 20146170] Association of LPR5 Polymorphism with Bone Mass Density and Cholesterol Level in Population of Chinese Han


[PMID 20960157] A polymorphism near osteoprotegerin gene confer risk of obesity in Uyghurs



[PMID 22079369] TNFRSF11B gene haplotype and its association with bone mineral density variations in postmenopausal Mexican-Mestizo women


[PMID 19181680OA-icon.png] Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.


[PMID 19629617OA-icon.png] Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.


[PMID 20072603OA-icon.png] Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis.


[PMID 20534768OA-icon.png] OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.


GET Evidence
rs4355801
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.320312
summary



[PMID 24130145] Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal maya-mestizo women


[PMID 23531404] Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women.


[PMID 25464125] RANK/RANKL/OPG pathway: genetic associations with stress fracture period prevalence in elite athletes