Rs438034

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is asnp
is mentioned by
dbSNPrs438034
hapmaprs438034
hgdprs438034
ensemblrs438034
gopubmedrs438034
scholarrs438034
googlers438034
pharmgkbrs438034
hgvbaseg2prs438034
medrefsnprs438034
23andMers438034
SNP Nexus

GeneCENPF
Chromosome1
Orientationminus
Position212897239
GenotypeEffect
rs438034(C;C)normal
rs438034(C;T)poorer survival rate if breast cancer patient
rs438034(T;T)poorer survival rate if breast cancer patient


Genotypes Magnitude Summary
Rs438034(C;C) 00 normal
Rs438034(C;T) poorer survival rate if breast cancer patient
Rs438034(T;T) poorer survival rate if breast cancer patient
rs438034 is a SNP in the centromere protein F CENPF gene.

Based on a long-term (up to 15 years) study of 749 Swedish women with breast cancer, carriers of rs438034(T) alleles (as oriented wrt dbSNP) had poorer specific survival rates as compared to rs438034(C;C) individuals. The hazard ratio was 2.65 (CI: 1.19-5.90). However, although rs438034(T) carriers had worse survival odds, they were less likely to have either regional lymph node metastases (odds ratio 0.71, CI: 0.51-1.01) or tumors of stage II-IV (OR 0.73, CI 0.54-0.99). [PMID 19008095]

? (C;C) (C;T) (T;T)
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