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rs438034

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 normal
(C;T) poorer survival rate if breast cancer patient
(T;T) poorer survival rate if breast cancer patient
ReferenceGRCh38 38.1/141
Chromosome1
Position214657274
GeneCENPF
is asnp
is mentioned by
dbSNPrs438034
ebirs438034
HLIrs438034
Exacrs438034
Varsomers438034
Maprs438034
PheGenIrs438034
hapmaprs438034
1000 genomesrs438034
hgdprs438034
ensemblrs438034
gopubmedrs438034
geneviewrs438034
scholarrs438034
googlers438034
pharmgkbrs438034
gwascentralrs438034
openSNPrs438034
23andMers438034
23andMe allrs438034
SNP Nexus

SNPshotrs438034
SNPdbers438034
MSV3drs438034
GWAS Ctlgrs438034
GMAF0.3792
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs438034 is a SNP in the centromere protein F CENPF gene.

Based on a long-term (up to 15 years) study of 749 Swedish women with breast cancer, carriers of rs438034(T) alleles (as oriented wrt dbSNP) had poorer specific survival rates as compared to rs438034(C;C) individuals. The hazard ratio was 2.65 (CI: 1.19-5.90). However, although rs438034(T) carriers had worse survival odds, they were less likely to have either regional lymph node metastases (odds ratio 0.71, CI: 0.51-1.01) or tumors of stage II-IV (OR 0.73, CI 0.54-0.99). [PMID 19008095]

GWAS snp
PMID [PMID 21659360OA-icon.png]
Trait
Title Association between SNP-genotype and chronic lymphocytic leukemia outcome in a randomized chemotherapy trial.
Risk Allele T
P-val 0.000005
Odds Ratio 1.8800 [1.44-2.46]


GET Evidence
CENPF-R2943G
aa_change Arg2943Gly
aa_change_short R2943G
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.491541
summary