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rs4415084

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0
Make rs4415084(C;T)
Make rs4415084(T;T)
ReferenceGRCh38 38.1/141
Chromosome5
Position44662413
is asnp
is mentioned by
dbSNPrs4415084
ebirs4415084
HLIrs4415084
Exacrs4415084
Varsomers4415084
Maprs4415084
PheGenIrs4415084
hapmaprs4415084
1000 genomesrs4415084
hgdprs4415084
ensemblrs4415084
gopubmedrs4415084
geneviewrs4415084
scholarrs4415084
googlers4415084
pharmgkbrs4415084
gwascentralrs4415084
openSNPrs4415084
23andMers4415084
23andMe allrs4415084
SNP Nexus

SNPshotrs4415084
SNPdbers4415084
MSV3drs4415084
GWAS Ctlgrs4415084
GMAF0.4871
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs4415084 and rs10941679 confer risk for estrogen receptor breast cancer (ER)-positive tumors (OR = 1.27, P = 2.5E-12 for rs10941679) based on a study of 6,145 cases. [PMID 18438407] From a DeCode user report, the risk allele appears to be T; this T;T individual reportedly has a 1.19x increased risk of breast cancer.
OMIM114480
DescBREAST CANCER
Variant
Relatedalso
[PMID 20095854OA-icon.png] Novel Breast Cancer Risk Alleles and Interaction with Ionizing Radiation among U.S. Radiologic Technologists


[PMID 20140701OA-icon.png] Genetic variants on chromosome 5p12 are associated with risk of breast cancer in African American women: the Black Women's Health Study

GWAS snp
PMID [PMID 21263130]
Trait
Title Novel Breast Cancer Susceptibility Locus at 9q31.2: Results of a Genome-Wide Association Study
Risk Allele T
P-val 8E-11
Odds Ratio 1.1700 [1.11-1.22]


[PMID 21791674OA-icon.png] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium


[PMID 22832384] Genetic variants at 5p12 and risk of breast cancer in Han Chinese the two risk SNPs reported in the European population were neither associated with breast cancer risk in our Chinese population

[PMID 19330030OA-icon.png] A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).

[PMID 20085711OA-icon.png] Leveraging genetic variability across populations for the identification of causal variants.


GET Evidence
rs4415084
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.554688
summary



[PMID 22965832] Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population.


[PMID 25002657] Breast cancer susceptibility variants and mammographic density phenotypes in Norwegian postmenopausal women