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rs4444235

From SNPedia

Orientationplus
Stabilizedplus
Make rs4444235(C;C)
Make rs4444235(C;T)
Make rs4444235(T;T)
ReferenceGRCh38 38.1/141
Chromosome14
Position53944201
is asnp
is mentioned by
dbSNPrs4444235
ebirs4444235
HLIrs4444235
Exacrs4444235
Varsomers4444235
Maprs4444235
PheGenIrs4444235
hapmaprs4444235
1000 genomesrs4444235
hgdprs4444235
ensemblrs4444235
gopubmedrs4444235
geneviewrs4444235
scholarrs4444235
googlers4444235
pharmgkbrs4444235
gwascentralrs4444235
openSNPrs4444235
23andMers4444235
23andMe allrs4444235
SNP Nexus

SNPshotrs4444235
SNPdbers4444235
MSV3drs4444235
GWAS Ctlgrs4444235
GMAF0.4353
Max Magnitude
? (C;C) (C;T) (T;T) 28
nature colorectal cancer

rs4444235, BMP4; P = 8.1 times 10-10)

GWAS snp
PMID [PMID 19011631OA-icon.png]
Trait Colorectal cancer
Title Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
Risk Allele C
P-val 8E-10
Odds Ratio 1.11 [1.08-1.15]
OMIM612589
DescCOLORECTAL CANCER, SUSCEPTIBILITY TO, 8; CRCS8
Variant
Relatedalso
[PMID 21119214OA-icon.png] Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters


[PMID 22367214OA-icon.png] Characterization of gene-environment interactions for colorectal cancer susceptibility loci


[PMID 22363440OA-icon.png] cis-Expression QTL Analysis of Established Colorectal Cancer Risk Variants in Colon Tumors and Adjacent Normal Tissue


[PMID 17847004OA-icon.png] Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance.


[PMID 19639606OA-icon.png] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.


[PMID 20501757OA-icon.png] Low-penetrance susceptibility variants in familial colorectal cancer.


[PMID 20648012OA-icon.png] Association studies on 11 published colorectal cancer risk loci.


[PMID 21071539OA-icon.png] Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.


[PMID 21314996OA-icon.png] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.


[PMID 22045029] Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.


[PMID 22158048] The 14q22.2 colorectal cancer variant rs4444235 shows cis-acting regulation of BMP4.


[PMID 22170598] Bone morphogenetic protein-4 polymorphism and colorectal cancer risk: a meta analysis.


[PMID 22235025] Susceptibility genetic variants associated with early-onset colorectal cancer.


GET Evidence
rs4444235
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.4375
summary



[PMID 23359760OA-icon.png] Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population


[PMID 22848671OA-icon.png] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.


[PMID 22999960OA-icon.png] Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.


[PMID 23161572] BMP2/BMP4 colorectal cancer susceptibility loci in northern and southern European populations.


[PMID 23434150OA-icon.png] Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?


[PMID 24854447] Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population


[PMID 24978480OA-icon.png] A Colorectal Cancer Susceptibility New Variant at 4q26 in the Spanish Population Identified by Genome-Wide Association Analysis


[PMID 25647270] Common genetic variant on BMP4 contributes to colorectal adenoma and cancer: A meta-analysis based on 15 studies


[PMID 25710502OA-icon.png] A Retrospective Observational Study of the Relationship between Single Nucleotide Polymorphisms Associated with the Risk of Developing Colorectal Cancer and Survival


[PMID 26078566OA-icon.png] Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population