Have questions? Visit https://www.reddit.com/r/SNPedia

rs4458523

From SNPedia

Orientationplus
Stabilizedplus
Make rs4458523(G;G)
Make rs4458523(G;T)
Make rs4458523(T;T)
ReferenceGRCh38 38.1/141
Chromosome4
Position6288259
GeneWFS1
is asnp
is mentioned by
dbSNPrs4458523
ebirs4458523
HLIrs4458523
Exacrs4458523
Varsomers4458523
Maprs4458523
PheGenIrs4458523
hapmaprs4458523
1000 genomesrs4458523
hgdprs4458523
ensemblrs4458523
gopubmedrs4458523
geneviewrs4458523
scholarrs4458523
googlers4458523
pharmgkbrs4458523
gwascentralrs4458523
openSNPrs4458523
23andMers4458523
23andMe allrs4458523
SNP Nexus

SNPshotrs4458523
SNPdbers4458523
MSV3drs4458523
GWAS Ctlgrs4458523
GMAF0.2897
Max Magnitude
? (G;G) (G;T) (T;T) 28
Rs4458523
PubMed [PMID 17603484OA-icon.png]
Affy Probeset SNP_A-2217489
Affy Orientation same
On GW 5.0 1
Alleles A/B G/T
Ancestral T
Population Caucasian (UK)
Allele G
Case Freq.
Control Freq.
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All 1.16
Disease Type II Diabetes (T2D)


rs4458523 is in linkage disequilibrium with a polymorphism that increases susceptibility to Type II Diabetes 1.16 times for carriers of the G allele [PMID 17603484OA-icon.png]

GWAS snp
PMID [PMID 24509480OA-icon.png]
Trait Type 2 diabetes
Title Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Risk Allele G
P-val 2E-9
Odds Ratio 1.09 [1.06-1.13]