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rs4489954

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 1 Normal risk of developing restless legs syndrome
(G;T) 1.5 0.69x risk risk of developing restless legs syndrome
(T;T) 1.8 >0.69x risk of developing restless legs syndrome
ReferenceGRCh38 38.1/141
Chromosome15
Position67779737
GeneMAP2K5
is asnp
is mentioned by
dbSNPrs4489954
ebirs4489954
HLIrs4489954
Exacrs4489954
Varsomers4489954
Maprs4489954
PheGenIrs4489954
hapmaprs4489954
1000 genomesrs4489954
hgdprs4489954
ensemblrs4489954
gopubmedrs4489954
geneviewrs4489954
scholarrs4489954
googlers4489954
pharmgkbrs4489954
gwascentralrs4489954
openSNPrs4489954
23andMers4489954
23andMe allrs4489954
SNP Nexus

SNPshotrs4489954
SNPdbers4489954
MSV3drs4489954
GWAS Ctlgrs4489954
GMAF0.4637
Max Magnitude1.8
? (G;G) (G;T) (T;T) 28
rs4489954, a SNP located in a region of chromosome 15q, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.69 (CI: 0.69-0.82) for the (T) minor allele. [PMID 17637780]
Neighborrs3784709
Distance200


[PMID 19223043] Exploring the genetic link between RLS and ADHD



GET Evidence
rs4489954
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.523438
summary