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rs4496877

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Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0
(G;T) 1.1 For type-1 diabetics, 1.3x increased nephropathy risk
(T;T) 1.2 For type-1 diabetics, 1.6x increased nephropathy risk
ReferenceGRCh38 38.1/141
Chromosome7
Position150983418
GeneNOS3
is asnp
is mentioned by
dbSNPrs4496877
ebirs4496877
HLIrs4496877
Exacrs4496877
Varsomers4496877
Maprs4496877
PheGenIrs4496877
hapmaprs4496877
1000 genomesrs4496877
hgdprs4496877
ensemblrs4496877
gopubmedrs4496877
geneviewrs4496877
scholarrs4496877
googlers4496877
pharmgkbrs4496877
gwascentralrs4496877
openSNPrs4496877
23andMers4496877
23andMe allrs4496877
SNP Nexus

SNPshotrs4496877
SNPdbers4496877
MSV3drs4496877
GWAS Ctlgrs4496877
GMAF0.2199
Max Magnitude1.2
rs4496877 is a SNP near the NOS3 gene.

Several Type-1 diabetes patients pools, totaling over 2,000 patients, plus a meta-analysis were involved in a study concluding that in such patients, the rs4496877 was associated with higher risk for nephropathy. The odds ratio associated with rs4496877(T) was 1.26 (p = 0.002, CI: 1.08-1.47).[PMID 20962522]

A proxy for this SNP (pairwise linkage of 0.96) is rs1800783.

? (G;G) (G;T) (T;T) 28
[PMID 19505917OA-icon.png] Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.