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rs4516035

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) if less milk in teenage females, less bone?
(C;T) if less milk in teenage females, less bone?
(T;T) normal
ReferenceGRCh38 38.1/141
Chromosome12
Position47906043
GeneVDR
is asnp
is mentioned by
dbSNPrs4516035
ebirs4516035
HLIrs4516035
Exacrs4516035
Varsomers4516035
Maprs4516035
PheGenIrs4516035
hapmaprs4516035
1000 genomesrs4516035
hgdprs4516035
ensemblrs4516035
gopubmedrs4516035
geneviewrs4516035
scholarrs4516035
googlers4516035
pharmgkbrs4516035
gwascentralrs4516035
openSNPrs4516035
23andMers4516035
23andMe allrs4516035
SNP Nexus

SNPshotrs4516035
SNPdbers4516035
MSV3drs4516035
GWAS Ctlgrs4516035
GMAF0.2149
Max Magnitude
? (C;C) (C;T) (T;T) 28

A very small study of 117 healthy European peri- and postmenarcheal girls (14.9 +/- 1.6 years) were followed for 4 years along with their calcium intake. Girls with rs4516035(C;T) and (C;C) genotypes had 13% lower spine mineral content if their milk intakes were below 260 mL/day, compared to either genotype-matched girls with higher milk intakes or to girls with the (T;T) genotype. If this is real, it suggests that rs4516035(C;T) and (C;C) female teens need more milk than rs4516035(T;T) girls to have optimal bone density.

[PMID 19105801OA-icon.png] rs4516035 and the more aggressive tumour location in head-neck and trunk (OR=1.54, p=0.020)


[PMID 18587672] Vitamin D receptor variants and breast cancer risk in the Polish population

[PMID 20046590OA-icon.png] The unfavorable effect of the A allele of the vitamin D receptor promoter polymorphism A-1012G has different mechanisms related to susceptibility and outcome of malignant melanoma


[PMID 20394945] Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment


[PMID 21365644OA-icon.png] Vitamin D receptor polymorphisms in patients with cutaneous melanoma


[PMID 22544453OA-icon.png] Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma


[PMID 17130574] Protection from type 1 diabetes by vitamin D receptor haplotypes.


[PMID 18205531] Vitamin D receptor gene haplotypes and susceptibility to HIV-1 infection in injection drug users.


[PMID 19309297] Higher milk requirements for bone mineral accrual in adolescent girls bearing specific caucasian genotypes in the VDR promoter.


[PMID 19450131OA-icon.png] Application of pharmacogenomics to vaccines.


[PMID 19615888OA-icon.png] Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data.


[PMID 19679055] Vitamin D receptor variants and the malignant melanoma risk: a population-based study.


[PMID 19682379OA-icon.png] TagSNP transferability and relative loss of variability prediction from HapMap to an admixed population.


[PMID 20015871OA-icon.png] Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia.


[PMID 20398755] Growth, calcium status and vitamin D receptor (VDR) promoter genotype in European children with normal or low calcium intake.


[PMID 20716226] Clinical and genetic predictors of response to narrowband ultraviolet B for the treatment of chronic plaque psoriasis.


[PMID 26303648] Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk