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rs4537545

From SNPedia

Orientationplus
Stabilizedplus
Make rs4537545(C;C)
Make rs4537545(C;T)
Make rs4537545(T;T)
ReferenceGRCh38 38.1/141
Chromosome1
Position154446403
GeneIL6R
is asnp
is mentioned by
dbSNPrs4537545
ebirs4537545
HLIrs4537545
Exacrs4537545
Varsomers4537545
Maprs4537545
PheGenIrs4537545
hapmaprs4537545
1000 genomesrs4537545
hgdprs4537545
ensemblrs4537545
gopubmedrs4537545
geneviewrs4537545
scholarrs4537545
googlers4537545
pharmgkbrs4537545
gwascentralrs4537545
openSNPrs4537545
23andMers4537545
23andMe allrs4537545
SNP Nexus

SNPshotrs4537545
SNPdbers4537545
MSV3drs4537545
GWAS Ctlgrs4537545
GMAF0.4601
Max Magnitude
? (C;C) (C;T) (T;T) 28
[PMID 19567438OA-icon.png] Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease


[PMID 21552154] Common genetic variation in the IGF1 associates with maximal force output

[PMID 17671508OA-icon.png] A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

[PMID 18276608] Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth.

[PMID 19197348OA-icon.png] Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

[PMID 19249341OA-icon.png] Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.

[PMID 20031577OA-icon.png] Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.


GET Evidence
rs4537545
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.484375
summary



[PMID 23372742OA-icon.png] Interleukin-6 Receptor Polymorphism Is Prevalent in HIV-negative Castleman Disease and Is Associated with Increased Soluble Interleukin-6 Receptor Levels


[PMID 24971461OA-icon.png] Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort


[PMID 26198920] Family-based association study of interleukin 6 (IL6) and its receptor (IL6R) functional polymorphisms in schizophrenia in the Polish population