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rs45438698

From SNPedia

Merged intors12720445
Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) not seen (too rare)
(A;G) resistant to drug block
(G;G) 0 common
ReferenceGRCh38 38.1/141
Chromosome12
Position5045880
GeneKCNA5
is asnp
is mentioned by
dbSNPrs45438698
ebirs45438698
HLIrs45438698
Exacrs45438698
Varsomers45438698
Maprs45438698
PheGenIrs45438698
hapmaprs45438698
1000 genomesrs45438698
hgdprs45438698
ensemblrs45438698
gopubmedrs45438698
geneviewrs45438698
scholarrs45438698
googlers45438698
pharmgkbrs45438698
gwascentralrs45438698
openSNPrs45438698
23andMers45438698
23andMe allrs45438698
SNP Nexus

SNPshotrs45438698
SNPdbers45438698
MSV3drs45438698
GWAS Ctlgrs45438698
StatusMerged into rs12720445
Max Magnitude0
This SNP, also known as R578K, affecting an amino acid in exon 1 of the KCNA5 potassium channel gene, may mediate the response to drugs such as quinidine and propafenone.

The risk allele is rs45438698(A), and carriers receiving quinidine or propafenone for the treatment of cardiac arrhythmias may be resistant to the drug (and thus treatment). Note that this allele is rare; it was not observed in African-American or Asian populations, however it is reported to be present at a frequency of 1.1% among Caucasians. [PMID 15735608]

Neighborrs45477792
Distance138