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rs45446698

From SNPedia

Orientationminus
Make rs45446698(A;A)
Make rs45446698(A;C)
Make rs45446698(C;C)
ReferenceGRCh38.p2 38.2/146
Chromosome7
Position99735325
GeneCYP3A7, CYP3A7-CYP3A51P, ZSCAN25
is asnp
is mentioned by
dbSNPrs45446698
ebirs45446698
HLIrs45446698
Exacrs45446698
Varsomers45446698
Maprs45446698
PheGenIrs45446698
hapmaprs45446698
1000 genomesrs45446698
hgdprs45446698
ensemblrs45446698
gopubmedrs45446698
geneviewrs45446698
scholarrs45446698
googlers45446698
pharmgkbrs45446698
gwascentralrs45446698
openSNPrs45446698
23andMers45446698
23andMe allrs45446698
SNP Nexus

SNPshotrs45446698
SNPdbers45446698
MSV3drs45446698
GWAS Ctlgrs45446698
Max Magnitude
http://www.healio.com/hematology-oncology/breast-cancer/news/online/%7B5c3d7a03-189f-4da6-8f37-e2a6a6c91c7b%7D/cyp3a7-allele-predicts-poor-outcomes-for-lung-and-breast-cancer-leukemia

CYP3A7 is normally turned on in an embryo, then turned off at birth. However, individuals with one of more copy of the gene (CYP3A7*1C) turn on their CYP3A7 gene in adult life. C allele increased risk of breast cancer, lung cancer, and CLL.

Analyses adjusted for prognostic factors showed harboring the SNP increased risk for disease-specific mortality 74% among patients with breast cancer (HR = 1.74; 95% CI, 1.05-2.9) and 43% among patients with lung cancer (HR = 1.43; 95% CI, 1.09-1.87).