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rs45511401

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 common on affy axiom data
Make rs45511401(G;T)
Make rs45511401(T;T)
ReferenceGRCh38 38.1/141
Chromosome16
Position16079375
GeneABCC1
is asnp
is mentioned by
dbSNPrs45511401
ebirs45511401
HLIrs45511401
Exacrs45511401
Varsomers45511401
Maprs45511401
PheGenIrs45511401
hapmaprs45511401
1000 genomesrs45511401
hgdprs45511401
ensemblrs45511401
gopubmedrs45511401
geneviewrs45511401
scholarrs45511401
googlers45511401
pharmgkbrs45511401
gwascentralrs45511401
openSNPrs45511401
23andMers45511401
23andMe allrs45511401
SNP Nexus

SNPshotrs45511401
SNPdbers45511401
MSV3drs45511401
GWAS Ctlgrs45511401
GMAF0.02204
Max Magnitude0



[PMID 22293538OA-icon.png] The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal.


GET Evidence
ABCC1-G671V
aa_change Gly671Val
aa_change_short G671V
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0435868
summary



[PMID 23396606] Genetic variability in the multidrug resistance associated protein-1 (ABCC1/MRP1) predicts hematological toxicity in breast cancer patients receiving (neo-)adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC).