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rs4646284

From SNPedia

Orientationplus
Stabilizedplus
Make rs4646284(-;-)
Make rs4646284(-;G)
Make rs4646284(G;G)
ReferenceGRCh38 38.1/142
Chromosome6
Position160160511
is asnp
is mentioned by
dbSNPrs4646284
ebirs4646284
HLIrs4646284
Exacrs4646284
Varsomers4646284
Maprs4646284
PheGenIrs4646284
hapmaprs4646284
1000 genomesrs4646284
hgdprs4646284
ensemblrs4646284
gopubmedrs4646284
geneviewrs4646284
scholarrs4646284
googlers4646284
pharmgkbrs4646284
gwascentralrs4646284
openSNPrs4646284
23andMers4646284
23andMe allrs4646284
SNP Nexus

SNPshotrs4646284
SNPdbers4646284
MSV3drs4646284
GWAS Ctlgrs4646284
GMAF0.3017
Max Magnitude
? (-;-) (-;G) (G;G)
GWAS snp
PMID [PMID TBD]
Trait Prostate Cancer
Title A large multi-ethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences
Risk Allele G
P-val 1.0E-19
Odds Ratio 1.18 [1.14-1.22]

rs4646284 is a prostate cancer susceptibility indel at 6q25.3 (risk allele: "G" insertion) ascertained in a University of California, San Francisco and Kaiser Permanente RPGEH GWAS of KP health plan members. Hoffmann, Witte, and colleagues report in the journal Cancer Discovery a fixed effects p-value of 1.0E-19 when meta-analyzing across multiple ethnic subpopulations within a diverse study cohort as well multiple replication cohorts. The rs4646284 indel significant exhibited cis-eQTL activity with adjacent genes at 6q25.3, with the strongest association being with the expression of SLC22A1 (p=1.3E-23) and SLC22A3 (p=3.2E-52).