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rs4646903

From SNPedia

Orientationminus
Stabilizedminus
Make rs4646903(A;A)
Make rs4646903(A;C)
Make rs4646903(C;C)
ReferenceGRCh38 38.1/141
Chromosome15
Position74719300
GeneCYP1A1
is asnp
is mentioned by
dbSNPrs4646903
ebirs4646903
HLIrs4646903
Exacrs4646903
Varsomers4646903
Maprs4646903
PheGenIrs4646903
hapmaprs4646903
1000 genomesrs4646903
hgdprs4646903
ensemblrs4646903
gopubmedrs4646903
geneviewrs4646903
scholarrs4646903
googlers4646903
pharmgkbrs4646903
gwascentralrs4646903
openSNPrs4646903
23andMers4646903
23andMe allrs4646903
SNP Nexus

SNPshotrs4646903
SNPdbers4646903
MSV3drs4646903
GWAS Ctlgrs4646903
GMAF0.2433
Max Magnitude

[PMID 19608585] Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in non-small cell lung cancer

[PMID 19650794] CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndromes patients


[PMID 20544687] Evidence that genetic variants of metabolic detoxication and cell cycle control are not related to gallbladder cancer risk in Chilean women

[PMID 21359562] Modulation of urinary polycyclic aromatic hydrocarbon metabolites by enzyme polymorphisms in workers of the German Human Bitumen Study[PMID 16949388] CYP1A1 and CYP1B1 polymorphisms and their association with estradiol and estrogen metabolites in women who are premenopausal and perimenopausal.

[PMID 17116718OA-icon.png] Dietary phytoestrogen intake is associated with reduced colorectal cancer risk.

[PMID 17429315] Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival.

[PMID 17603290] Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women.

[PMID 18268125OA-icon.png] Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns.

[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

[PMID 18628428OA-icon.png] Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.

[PMID 18691756OA-icon.png] Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk.

[PMID 18763031OA-icon.png] CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women.

[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

[PMID 18941913OA-icon.png] Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer.

[PMID 18990750OA-icon.png] Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.

[PMID 19127255OA-icon.png] Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium.

[PMID 19174490OA-icon.png] Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.

[PMID 19267064] [Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of workers exposed to vinyl chloride monomer].

[PMID 19387820OA-icon.png] Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome.

[PMID 19479063OA-icon.png] Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.

[PMID 19537956OA-icon.png] CYP1A1 genotype modifies the impact of smoking on effectiveness of HAART among women.

[PMID 19630952OA-icon.png] Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women.

[PMID 19679043OA-icon.png] African American-preponderant single nucleotide polymorphisms (SNPs) and risk of breast cancer.

[PMID 19954069] [Association of nasopharyngeal carcinoma risk with cytochrome P450 CYP1A1 gene polymorphisms].

[PMID 20878621] Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study.

[PMID 21429951] Quantitative trait analysis suggests polymorphisms of estrogen-related genes regulate human sperm concentrations and motility.

[PMID 21741876] Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk.

[PMID 21897271] Analysis of 4 single-nucleotide polymorphisms in relation to cervical dysplasia and cancer development using a high-throughput ligation-detection reaction procedure.

[PMID 22200898] Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE).

[PMID 22525558] Genetic polymorphisms involved in carcinogen metabolism and DNA repair and lung cancer risk in a Japanese population.

GET Evidence
rs4646903
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.21875
summary



[PMID 23528250] Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women

[PMID 23686565] Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection

[PMID 23906684] Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants

[PMID 24499375] Association of Oxidative Stress Related Genes with Idiopathic Recurrent Miscarriage [PMID 22949524] Gene-environment interaction in preterm delivery with special reference to organochlorine pesticides.


[PMID 23107763] Host genetic risk factors for community-acquired pneumonia.


[PMID 23130019OA-icon.png] Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the chilean population: comparison with caucasian and asian populations.


[PMID 23178447] Lung cancer risk in relation to nicotinic acetylcholine receptor, CYP2A6 and CYP1A1 genotypes in the Bangladeshi population.


[PMID 23661361] The potential effect of gender in CYP1A1 and GSTM1 genotype-specific associations with pediatric brain tumor.


[PMID 23848208] CYP1A1 gene polymorphisms and polycystic ovary syndrome risk: a meta-analysis and meta-regression.


[PMID 23852617] Common polymorphisms in the CYP1A1 and CYP11A1 genes and polycystic ovary syndrome risk: a meta-analysis and meta-regression.

[PMID 24068433] CYP1A1, GCLC, AGT, AGTR1 gene-gene interactions in community-acquired pneumonia pulmonary complications

[PMID 24657182] Association of CYP1A1 gene variants rs4646903 (T>C) and rs1048943 (A>G) with cervical cancer in a North Indian population

[PMID 25902778] Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk

[PMID 26578427] CYP1A1 rs1048943 and rs4646903 polymorphisms associated with laryngeal cancer susceptibility among Asian populations: a meta-analysis [PMID 27265845] The Association of CYP1A1 Gene With Cervical Cancer and Additional SNP-SNP Interaction in Chinese Women. [PMID 27383824] The association of CYP1A1 genetic polymorphisms and additional gene-gene interaction with ischemic stroke in the eastern Han of China.