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rs4648022(T;T)

From SNPedia

0.47x reduced risk for NHL
Is agenotype
ofrs4648022
GeneNFKB1, LOC101929401
Chromosome4
Position102,575,280
mentionedby
Magnitude1.4
ReputeGood
Geno Mag Summary
(C;C) 0 Normal risk for NHL. The minor, protective allele is rare.
(C;T) 1.2 0.58x reduced risk of NHL
(T;T) 1.4 0.47x reduced risk for NHL

The rare minor T allele is protective for NHL in general and subtypes, with a reduction in risk of 0.47x (95% CI .04-5.24) p-trend=.0037. Risk reduction is likely greater in very rare TT homozygotes, but the CI is large due to the rarity of this genotype, and the p-trend includes the risk reduction in the more common heterozygotes.