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rs4648317

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 normal
(C;T) prone to higher nicotine dependence?
(T;T) 1.2 prone to higher nicotine dependence, more impulsive/sensation seeking
ReferenceGRCh38 38.1/141
Chromosome11
Position113460810
GeneDRD2
is asnp
is mentioned by
dbSNPrs4648317
ebirs4648317
HLIrs4648317
Exacrs4648317
Varsomers4648317
Maprs4648317
PheGenIrs4648317
hapmaprs4648317
1000 genomesrs4648317
hgdprs4648317
ensemblrs4648317
gopubmedrs4648317
geneviewrs4648317
scholarrs4648317
googlers4648317
pharmgkbrs4648317
gwascentralrs4648317
openSNPrs4648317
23andMers4648317
23andMe allrs4648317
SNP Nexus

SNPshotrs4648317
SNPdbers4648317
MSV3drs4648317
GWAS Ctlgrs4648317
GMAF0.2365
Max Magnitude1.2
? (C;C) (C;T) (T;T) 28
rs4648317, a SNP in the dopamine D2 receptor DRD2 gene, has been linked to higher rates of smoking and higher nicotine dependence scores, based on a study of ~220 adolescents. The risk allele rs4648317(T).[PMID 18434921]


[PMID 19373123] Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution


[PMID 19512960] Genetic diagnostics of functional variants of the human dopamine D2 receptor gene

[PMID 19968402OA-icon.png] Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants


[PMID 18077373OA-icon.png] Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.


[PMID 22244514] Sensorimotor gating and D2 receptor signalling: evidence from a molecular genetic approach.