rs4656461

plus

Geno	Mag	Summary
(A;A)	0	normal
(A;G)	1.5	1.5x increased risk for open angle glaucoma
(G;G)	2.2	2.2x increased risk for open angle glaucoma

Reference

GRCh38 38.1/141

Chromosome

1

Position

165717968

is a	snp
is	mentioned by
dbSNP	rs4656461
dbSNP (classic)	rs4656461
ClinGen	rs4656461
ebi	rs4656461
HLI	rs4656461
Exac	rs4656461
Gnomad	rs4656461
Varsome	rs4656461
LitVar	rs4656461
Map	rs4656461
PheGenI	rs4656461
Biobank	rs4656461
1000 genomes	rs4656461
hgdp	rs4656461
ensembl	rs4656461
geneview	rs4656461
scholar	rs4656461
google	rs4656461
pharmgkb	rs4656461
gwascentral	rs4656461
openSNP	rs4656461
23andMe	rs4656461
SNPshot	rs4656461
SNPdbe	rs4656461
MSV3d	rs4656461
GWAS Ctlg	rs4656461

GMAF

0.1405

Max Magnitude

2.2

?

(A;A) (A;G) (G;G)

28

rs4656461 is a SNP near the TMCO1 gene.

A (GWA) study for open-angle glaucoma (OAG) blindness ultimately based on ~1500 cases concluded that the rather rare rs4656461(G) allele was statistically associated with the condition, with a per allele odds ratio of 1.5 (CI: 1.35–1.68, p = 6 × 10e?14).[PMID 21532571]

[PMID 22714896] Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterisation of the protein in the eye

[PMID 25711633] Genetic Variants Associated With Different Risks for High Tension Glaucoma and Normal Tension Glaucoma in a Chinese Population