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rs4656461

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;G) 1.5 1.5x increased risk for open angle glaucoma
(G;G) 2.2 2.2x increased risk for open angle glaucoma
ReferenceGRCh38 38.1/141
Chromosome1
Position165717968
is asnp
is mentioned by
dbSNPrs4656461
ebirs4656461
HLIrs4656461
Exacrs4656461
Varsomers4656461
Maprs4656461
PheGenIrs4656461
hapmaprs4656461
1000 genomesrs4656461
hgdprs4656461
ensemblrs4656461
gopubmedrs4656461
geneviewrs4656461
scholarrs4656461
googlers4656461
pharmgkbrs4656461
gwascentralrs4656461
openSNPrs4656461
23andMers4656461
23andMe allrs4656461
SNP Nexus

SNPshotrs4656461
SNPdbers4656461
MSV3drs4656461
GWAS Ctlgrs4656461
GMAF0.1405
Max Magnitude2.2
? (A;A) (A;G) (G;G) 28
rs4656461 is a SNP near the TMCO1 gene.

A (GWA) study for open-angle glaucoma (OAG) blindness ultimately based on ~1500 cases concluded that the rather rare rs4656461(G) allele was statistically associated with the condition, with a per allele odds ratio of 1.5 (CI: 1.35–1.68, p = 6 × 10e?14).[PMID 21532571]


[PMID 22714896] Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterisation of the protein in the eye


[PMID 25711633] Genetic Variants Associated With Different Risks for High Tension Glaucoma and Normal Tension Glaucoma in a Chinese Population