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rs4675690

From SNPedia

Orientationplus
Stabilizedplus
Make rs4675690(C;C)
Make rs4675690(C;T)
Make rs4675690(T;T)
ReferenceGRCh38 38.1/141
Chromosome2
Position207643083
is asnp
is mentioned by
dbSNPrs4675690
ebirs4675690
HLIrs4675690
Exacrs4675690
Varsomers4675690
Maprs4675690
PheGenIrs4675690
hapmaprs4675690
1000 genomesrs4675690
hgdprs4675690
ensemblrs4675690
gopubmedrs4675690
geneviewrs4675690
scholarrs4675690
googlers4675690
pharmgkbrs4675690
gwascentralrs4675690
openSNPrs4675690
23andMers4675690
23andMe allrs4675690
SNP Nexus

SNPshotrs4675690
SNPdbers4675690
MSV3drs4675690
GWAS Ctlgrs4675690
GMAF0.483
Max Magnitude
? (C;C) (C;T) (T;T) 28
rs4675690 is in close proximity to CREB1, and adjacent to LOC151194.

g2b2mh blog [PMID 18678793OA-icon.png] individuals with the TT genotype at rs4675690 (C/T) showed less disgust, but not happiness, desire or fear.

[PMID 17548750] T allele associated with increased chance of suicide (OR = 2.3, 95% CI 1.3-2.9, TT homozygotes vs CC homozygotes?) during the first 30 days (p > 0.05 after the first month) of citalopram treatment, in a study of 1447 citalopram users (male only subgroup, 539 in total). Two haplotypes (see below) also showed significant association with suicidality in the male subgroup.

[PMID 17300755] strongly associated with anger expression in male MDD patients



[PMID 21807415] Early influence of the rs4675690 on the neural substrates of sadness


[PMID 22293360] Genotype distributions and allele frequencies of possible major depressive disorder-associated single nucleotide polymorphisms, cyclic adenosine monophosphate response element binding protein 1 rs4675690 and Piccolo rs2522833, in a Japanese population

[PMID 20643483] A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression.


GET Evidence
rs4675690
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.547619
summary



[PMID 22574704] CREB1 modulates the influence of childhood sexual abuse on adult's anger traits.